Nitric oxide production inhibitor

Shimoda H, Nishida N, Ninomiya K, Matsuda H, Yoshikawa M. (2001) Javaberine A, new TNF-alpha and nitric oxide production inhibitor, from the roots of Talinum paniculatum. Heterocycles 55 2043-2050. 

Ozawa, M. Kawamata, S. Etoh, T. Hayashi, M. Komiyama, K. Kishida, A. Knroda, C. Ohsaki, A. Structures of new Erythrinan alkaloids and nitric oxide production inhibitors from Erythrina crista-galli. Chem. Pharm. Bull 2010, 58, 1119-1122. 

Chung, S-J., Fung, H-L., Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production. Probes with inhibitors and tolerance development. Biochem. Pharmacol. 45 (1993), p. 157-163... 

In summary, natural products have a few known general mechanisms of action. These include toxins, inhibitors of growth, surface-energy modifiers, nervous pathway interference (anesthetics, including nitric oxide synthase inhibitors and neurotransmitter blockers), inhibitors of attachment, inhibitors of metamorphosis, and repellants.46 55117118 It is likely that many compounds have multiple mechanisms of action. 

Marino, S. de, Borbone, N., Zollo, F., lanaro, A., Meglio, P. di and lorizzi, M. (2005) New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production. Planta Medica 71, 706-710. 

Since IL-6 stimulates Prostaglandin E2 (PGE2) and antidepressants inhibit the IL-6 production, an inhibiting action of antidepressants on PGE2 would be expected, too (Poliak and Yirmiya, 2002). Over twenty years ago it was suggested that antidepressants inhibit PGE2 (Mtabaji et al., 1977). A recent in-vitro study showed that both tricyclic antidepressants and selective serotonin inhibitors attenuated cytokine-induced PGE2 and nitric oxide production by inflammatory cells (Yaron et al., 1999). 

B. C. Berk, R. Aebersold and M. A. Corson, Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. J Biol Chem 274, 30101-30108 (1999). 

E. Balkan, S. Balkan, T. Ozben, M. Serteser, S. Gumuslu, N. Oguz. The Effects of Nitric Oxide Synthase Inhibitor. L-NAME on NO Production During Focal Cerebral Ischemia in Rats Could L-N.A.ME be the Future Treatment of Sudden Deafness . Internationa Journal of Neuroscience 89... 

Severe hypotension within hours after interleukin-3 injection has been observed in three of 26 patients treated with angiotensin-converting enzyme inhibitors (SEDA-19, 340). Indirect synergy between ACE and interleukin-3 on nitric oxide production was suggested to be involved. 

Oxidative stress and free-radicals The production of free-radicals and other reactive species has been much implicated in cytotoxicity. This topic is discussed in more detail elsewhere see ANTIOXIDANTS PREE-RADICAL SCAVENGERS nitric oxide synthase inhibitors. The production of these species in oxidative stress is well established. Advances in therapy may well be in the direction of boosting and augmenting natural defence processes, for example, by superoxide dismutase (SOD), catalase, a-tocopherol, glutathione, ascorbic acid and perhaps melatonin. Surprisingly, some forms of the enzyme SOD can be administered in vivo and are protective. 

The 1,5,2,4-dioxadiazine 262, the 1,3,2,4,6-dioxathiadiazine 263, 1,5,2,4-dithiadiazine tetraoxides 264 and 265, and a selection of further derivatives have been patented as nitric oxide synthase inhibitors with potential use as agents for treatment of arthritis, pain, some neurodegenerative conditions, and other disorders involving NO production <2000W00063195>. 

Recently Iwabuchi et al. reported the first total synthesis of (—)-idesolide (650) (559), an efficient inhibitor of nitric oxide production induced by lipopolysaccharide in BV2 microglial cells, isolated firom the deciduous tree Idesia polycarpa (560). As idesolide may originate from dimerization of the precursor 651, two major challenges had to be addressed in this investigation. The first was installation of the required absolute configuration in 651 and the second, identifying useful dimerization conditions for this monomeric precursor. Synthesis of 651 could be achieved successfully by carrying out an oxidative kinetic resolution on the easily synthesized racemic... 

Bianchi M, Ulrich P, Bloom O, Meistrell M 3rd, Zimmerman GA, Schmidtmayerova H, Bukrinsky M, Donnelley T, Bucala R, Sherry B, Monoque KR, Tortolani AJ, Cerami A, Tracey KJ. An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality. Mol Med 1995 1(3) 254-66. 

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