Nitric oxide precursor arginine

See also Glutamate as a Precursor of Other Amino Acids, Nitric Oxide Synthase, Arginine, Citrulline, Guanylate Cyclase... 

The citruUine leaves the intestine and is transported to the kidney, where it is converted back to arginine (Figure 8.18). This inter-organ process protects arginine from degradation in the liver. Maintenance of the arginine level in the blood is important since it is a precursor for several compounds that are of particular importance for cells of the immune system and other cells (see Table 8.4) and as the precursor for the formation of the messenger molecule, nitric oxide. 

Arginine Arginine is a precursor for a number of compounds, including proline and nitric oxide. Nitric oxide is a signalling molecule, proline is needed for formation of collagen, some of which is needed for provision of new tissue. Arginine has been shown to be benehcial for the healing of wounds and for this reason is included in some parenteral feeds (Table 18.4). 

Palmer, R. M. J., Rees, D. D., Ashton, D. S., and Moncada, S. (1988b). L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem. Biophys. Res. Commun. 153, 1251-1256. 

Arginine Is the Precursor for Biological Synthesis of Nitric Oxide... 

Arginine is the precursor of nitric oxide, a biological messenger. 

The decarboxylation of diacyl peroxides was also used in the synthesis of a nonapeptide 148 and 5-methyl L-arginine 151 (Scheme 2.35) [65,66]. The peptide 148 is an analogue of an oxytocin receptor antagonist. The photolysis of precursor 146 gave 34% of product 147, which was reprotected with Fmoc and then incorporated into the oligopeptide. 5-Methyl arginine 151 was synthesized as a probe to study the nitric oxide synthase (NOS) active site and mechanism. The photolysis of 149 gave 150... 

Arginine is a precursor of nitric oxide (NO) in the human organism. NO is a powerful vasodilator and a neurotransmitter. It is formed as indicated in Equation (20.26) ... 

Nitric oxide, a precursor of nitrogen dioxide, occurs naturally in the human body, where it acts as endothelial derived relaxing factor (EDRF), a neurotransmitter, and in unidentified ways in the nose, sinuses, and lower airways. Up to 15 ppm can be found normally in the nose and sinuses (DuBois et al. 1998). The substrate is 1-arginine, and the enzymes consist of different forms of nitric oxide synthase, which turn arginine into citrulline. Inhaled nitric oxide gas is used at concentrations of up to 50 ppm to decrease pulmonary arterial pressure. Nitric oxide reacts in tissues to form nitrites and nitrates. 

In mammals, hepatic arginase is the terminal enzyme of the urea cycle, which represents the major end-product of nitrogen metabolism — the average adult human excretes some 10 kg of urea per year. The enzyme is not restricted to the liver, since ornithine is a precursor of the nonessential amino acid proUne, and a biosynthetic precursor of polyamines, required for rapidly dividing tissues. Arginine is also the precursor of the important messenger in many vertebrate signal-transduction pathways nitric oxide, NO (Scheme 16.1), of which more shortly. 

Interestingly, dietary sources of nitrates, nitrites, or L-arginine (a precursor for nitrates) do not interact with the phosphodiesterase inhibitors. This is because these dietary sources do not increase circulating levels of nitric oxide in humans. ... 

Arginine is a precursor to nitric oxide. In this unusual reaction, an unprecedented five-electron oxidation of arginine occurs (reaction 3 below). 

The amino acid Arginine is a precursor to a novel second messenger and neurotransmitter, which is a gas, nitric oxide. Nitric oxide is produced from arginine in an unusual five-electron oxidation that also yields citrulline (see Figure 21.3). The enzyme catalyzing the reaction, nitric oxide synthase, contains bound FMN, FAD, non-heme iron, and tetrahydrobiopterin. 

Arginine is a precursor to nitric oxide and citmlline (Figure 21.3) and Arginine can be converted to creatine phosphate (Figure 21.3). 

Arginine as the Precursor to Nitric Oxide, a Novel Second Messenger (Figure 21,3)... 

Recently there has been a widespread interest in thiol antioxidants, glutathione, and related enzymes, hydrogen sulfide, sesame oil components, L-arginine (L-Arg) and other nitric oxide modulators [129]. While the former compounds may have direct antioxidant actions, L-Arg is both a direct precursor of nitric oxide as well as an antioxidant [110]. These compounds may assist in lowering high blood pressure. 

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