Nitric oxide, decomposition oxygen

The decomposition of nitric oxide in oxygenated perfused organ baths is commonly assumed to occur by the third-order reaction of... 

Possibly, cellular thiols may be oxidized by the inactive adduct of nitric oxide and oxygen to regenerate a nitrosothiol or related species with EDRF activity. Some of the inconsistent results observed in bioassay systems may be due to the secondary and nonenzymatic formation of a nitrosothiols or other species capable of regenerating nitric oxide, which are leached into perfusion cascades. Consequently, bioassay systems should not be the gold standard to distinguish whether nitric oxide is the EDRF, because secondary reactions of nitric oxide decomposition products may regenerate nitric oxide. 

Bodenstein, in the course of a comprehensive study of the formation and decomposition of the higher oxides of nitrogen, showed, in conjunction with Lindner, that the reaction between nitric oxide and oxygen proceeds in accordance with the equation... 

To introduce the concept of reaction rate, we will consider the decomposition of nitrogen dioxide, a gas that causes air pollution. Nitrogen dioxide decomposes to nitric oxide and oxygen as follows ... 

Examples of such reactions are the decomposition of nitrogen dioxide to nitric oxide and oxygen in the gas phase. 

Higgins s most important discovery, which. neither he nor his later admirers claimed or emphasised, was that dry chlorine and nitric oxide do not react when mixed when the airs are perfectly dry, and mixed over mercury, no decomposition seems to take place until water is produced. Hence I infer, that water assists the decomposition from its attraction to marine add (which he thought was formed when nitric oxide withdraws oxygen from dephlogisti-cated marine acid or chlorine). This experiment later played an important part in the controversy between Murray and John Davy on the nature of chlorine (see Vol. IV). Higgins, it is seen, failed to interpret it correctly. 

Comparison of the observed pseudo-first-order decay of biological activity with a half-life of 30 sec at normal oxygen tensions versus decomposition via nitrogen dioxide by pseudo-second-order kinetics predicted by Reaction 4. The loss of nitric oxide through formation of nitrogen oxide is twice as fast as calculated by Reaction 4 because each nitrogen dioxide formed rapidly attacks a second nitric oxide to form nitrite. 

The redox potentials of various oxidants derived from nitric oxide and peroxynitrite are summarized in Table 4. Clearly, as the adducts of molecular oxygen and nitric oxide become more reduced, they form substantially stronger oxidizing agents. In effect, addition of one electron makes these nitrogen oxides more ready to accept the next. The precise pathway of decomposition followed is influenced by what types of target molecules come in contact with peroxynitrite and is... 

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