Niridazole

The most studied properties of 2-aminothiazoles and 2-imino-4-thiazolines are related to their antiinflammatory activity (Table VI-9). Two classes of compounds have even been given trade names Sudoxicam (418) and Niridazole. also named Ambilhar (419) (Scheme 238). [Pg.138]

Other compounds that have shown promising properties in vitro against E. histolytica are niridazole (10), tinidazole (11, Fasigyn, Simplotan), gossypol (12), bithionol [(13), 2,2 -thiobis(4,6-dichlorophenol)], and pimaricin (14, Natamycia [7681-93-8]). The chemotherapy of amebiasis has been reviewed (9). [Pg.261]

C3H3N3O2S 121-66-4) see Niridazole Tenonitrozole [45-(4a,7a,10aP)]-4-aminooctahydro-5-oxo-7 -pyri-do[2,l-A][l,3]thiazepine-7-carboxylic acid methyl ester (C11H13N2O3S 167304-98-5) see Omapatrilat... [Pg.2296]

C3H4CINO 1943-83-5) see Fotemustine Nimustine Niridazole Ranimustine Rilmenidine... [Pg.2328]

C7H 4C1N 54777-54-7) see Clemastine 2-chloroethyl 4-nitrophenyl ether (C HgClN03 3383-72-0) see Dofetilide 7V-(2-chloroethyl)-N -(5-nitro-2-thiazolyl)urea (CgH7ClN403S 3311-98-6) see Niridazole 7V-(2-chloroethyl)piperidine... [Pg.2328]

The in vitro trypanocidal and antitumor activities of lfr(cot)L], cot = cyclotetraene, derivatives of dithiocarbamates and xanthates, have been investigated.700 The Ir complexes were characterized by IR spectroscopy, and MO calculations (Hiickel) were performed on the ligands. Similar studies were performed on [Ir(nbr)L], nbr = norbornadiene, L = derivatives of alquil and aryl xanthates 701 and also on [Ir2(cod)2L]X2, where L = 2-hydroxystilbamidine, X = C1, N03, C104, BPh4, and [Ir(cod)L2 ]X, where L = benznidazole, R0-2516, nifurtimox, niridazole. The complex [Ir2(cod)2(2-hydroxystilbami-dine)](BPh4)2 showed the highest activity, as studied by optical microscopy of rats kidneys. [Pg.228]

Nadolol, 110 Nafenopin, 214 Nafomine, 212 NafT-onyl, 213 Nalbuphine, 319 Nalidixic acid, 370, 469 Nalmexone, 319 Nalorphine, 318 Naloxone, 318, 323 Naltrexone, 319 Naranol, 454 Nef reaction, 2 Nefopam, 447 Nequinate, 369 Nexeridine, 17 Nicergoline, 478 Niclos amide, 94 Nifedipine, 283 Nifuratrone, 238 Nifurdazil, 239 Nifurimide, 239 Nifui oxime, 238 Nifurpirinol, 240 Nifurcguinazol, 383 Nifursemizone, 238 Nifurthiazole, 241 Nimazone, 260 Nimorazole, 244 Niridazole, 269 Nisobamate, 22 Nithiazole, 268 Nitronic acid, 2 Nivazol, 159 Nocardicins, 435 Noracymethadol, 58... [Pg.1014]

Niridazole Niridazole, l-(5-nitro-2-thiazolyl)-2-imidazolidinone (38.1.11), is made by reacting 2-amino-5-nitrothiazol with 2-chloroethylisocyanate to make the disubstituted urea (38.1.10). Heating this compound results in an intramolecular N-alkylation reaction to form the desired imidazolidine derivative, niridazole [7-11]. [Pg.585]

Niridazole exhibits schistosomicide and amebicidal action. The mechanism of action is not known. It seems likely that it is concentrated in the parasite organism, which causes inhibition of phosphorylase activation, which is expressed in the depletion of glycogen reserves. [Pg.585]

Nickel subsulfide (5ee Nickel and nickel compounds) Nickel sulfate (see Nickel and nickel compounds) Niridazole Nithiazide... [Pg.551]

Derivatives of 2-amino-5-nitrothiazole have antiparasitic activity. Niridazole (253) is used in the treatment of schistosomiasis, but its side-effects make it unattractive for treating other diseases, e.g. amoebiasis, for which safer drugs are available. The nitroimidazole metronidazole (254) is particularly useful in amoebiasis and trichomoniasis, and the latter disease may also be treated with nimorazole, l-morpholinoethyl-5-nitroimidazole. [Pg.180]

Katz, N. (1 975) Clinical evaluation of niridazole and hycanthone in schistosomiasis mansoni endemic areas. Journal of Toxicology and Environmental Health 1, 203-209. [Pg.267]

Khat may interact with drugs used in treatment of other diseases and produce emotional and mental disorders. For example, when combined with niridazole—a drug used in treating schistosomiasis (a parasitic disease endemic throughout Asia, Africa, and tropical America)—severe anxiety reactions, insomnia, and even psychoses may develop. Also, khat would be likely to react with other stimulants such as alcohol, coffee, or cigarettes, causing palpitations and agitation. [Pg.95]

Beyond pharmaceutical screening activity developed on aminothiazoles derivatives, some studies at the molecular level were performed. Thus 2-aminothiazole was shown to inhibit thiamine biosynthesis (941). Niridazole (419) affects iron metabolism (850). The dehydrase for 5-aminolevulinic acid of mouse liver is inhibited by 2-amino-4-(/3-hydroxy-ethyDthiazole (420) (942) (Scheme 239). l-Phenyl-3-(2-thiazolyl)thiourea (421) is a dopamine (3 -hydroxylase inhibitor (943). Compound 422 inhibits the enzyme activity of 3, 5 -nucleotide phosphodiesterase (944). The oxalate salt of 423, an analog of levamisole 424 (945) (Scheme 240),... [Pg.83]

See also in sourсe #XX -- [ Pg.138 , Pg.145 , Pg.150 , Pg.152 ]

See also in sourсe #XX -- [ Pg.269 ]

See also in sourсe #XX -- [ Pg.2 , Pg.269 ]

See also in sourсe #XX -- [ Pg.585 ]

See also in sourсe #XX -- [ Pg.1448 ]

See also in sourсe #XX -- [ Pg.814 ]

See also in sourсe #XX -- [ Pg.44 , Pg.286 ]

See also in sourсe #XX -- [ Pg.35 , Pg.39 , Pg.260 , Pg.263 , Pg.264 , Pg.265 , Pg.266 , Pg.267 , Pg.422 ]

See also in sourсe #XX -- [ Pg.136 , Pg.137 , Pg.138 ]

See also in sourсe #XX -- [ Pg.402 , Pg.497 , Pg.602 ]

See also in sourсe #XX -- [ Pg.155 ]

See also in sourсe #XX -- [ Pg.6 , Pg.27 , Pg.232 ]

See also in sourсe #XX -- [ Pg.569 , Pg.571 ]

See also in sourсe #XX -- [ Pg.200 ]

See also in sourсe #XX -- [ Pg.110 ]

See also in sourсe #XX -- [ Pg.91 , Pg.122 ]

See also in sourсe #XX -- [ Pg.130 , Pg.132 , Pg.219 , Pg.223 ]

See also in sourсe #XX -- [ Pg.150 , Pg.151 ]

See also in sourсe #XX -- [ Pg.223 , Pg.239 ]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...