Niridazole ‘Ambilhar

Polarography investigations of nitrothiazoles are carried out in some works [535,929,931,983,984], The investigation of fourteen 2-R-5-nitrothiazoles it is shown that the compounds of greater toxicity have higher negative reduction potential values [535], The polarographic characteristics of 2-acetamido-5-nitrothiazole [931, 983] and niridazole (ambilhar) [929] have been obtained. 

The most studied properties of 2-aminothiazoles and 2-imino-4-thiazolines are related to their antiinflammatory activity (Table VI-9). Two classes of compounds have even been given trade names Sudoxicam (418) and Niridazole. also named Ambilhar (419) (Scheme 238). 

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