Nirenberg

Kinderlehrer D., Nirenberg L., Spruck J. (1979) Regularity in elliptic free boundary problems. II Equations of higher order. Ann. Scuola Norm. Sup. Pisa 6, 637-687. 

In one of the early experiments designed to elucidate the genetic code, Marshall Nirenberg of the U.S. National Institutes of Health (Nobel Prize in physiology or medicine, 1968) prepared a synthetic mRNA in which all the bases were uracil. He added this poly(U) to a cell-free system containing all the necessary materials for protein biosynthesis. A polymer of a single amino acid was obtained. What amino acid was polymerized ... 

Monoamines ean also be found in terminals at both symmetrie and asymmetrie synapses, but this may be partly beeause they eo-exist with the elassieal transmitters glutamate and GABA. The faet that vesieular and neuronal uptake transporters for the monoamines ean be deteeted outside a synapse along with appropriate postsynaptie reeeptors does suggest, however, that some monoamine effeets ean oeeur distant from the synaptie junetion (see Piekel, Nirenberg and Milner 1996, and Chapter 6). 

Pickel, VM, Nirenberg, MJ and Milner, TA (1996) Ultrastructural view of central catecholaminergic transmission immunoc54ochemical localization of S5mthesising enzymes, transporters and receptors. J. Neurocytol. 25 843-856. 

Sharma S, Klee W, Nirenberg M. Dual regulation of adenylate cyclase accounts for narcotic tolerance and dependence. Proc Natl Acad Sci USA 1975 72 3092-3096. 

We shall prove the integrability of / using the Newlander-Nirenberg theorem. (Replacing the argument with J and id, we find J and K are integrable.) If v and w are complex-valued vector field on X, we have... 

This shows [v,w] is of type (1,0) again by (3.33). The Newlander-Nirenberg theorem implies / is integrable. ... 

Nirenberg, Z.. Solenchyk, B.,andYaron, 1. Solnbility in the system sodium orthophosphate, acetone, and water, / Chem.Eng. Data, 22(l) 47-48, 1977. 

D.Gruenberger,C. O Neal and A. Nirenberg, Biochim. Biophys. Acta, 1966, 119, 581 347a. D. Grunberger, A. Holy and F. Soim, Biochim. Biophys. Acta, 1968, 161, L47... 

O Donnell, K., Cigelnik, E., and Nirenberg, H. 1. (1998). Molecular systematics and phylo-geography of the Gibberella fujikuroi species complex. Mycologia 90,465 93. 

Marshall Warren Nirenberg, Har Gobind Korhana, and Robert Holley, figure out the genetic code... 

Nirenberg, S.A. (1991) Normal and pathologic laughter in children. Clin Pediatr (Phila) 30 630-632. 

The work of Marshal Nirenberg and Heinrich Matthaei between 1961 and 1966 resulted in the cracking of the genetic code [18]. They demonstrated that a codon consisting of three nucleotide bases determines each of the 20 amino acids. 

The techniques of Nirenberg and Leder (see Glossary) have been used to measure the coding activity of uracil dimers and hydrates contained in known positions in tri- and tetranucleotides.148 Mixtures of... 

Nirenberg Technique.149 This is a rapid and sensitive method for determining the specificity of particular code words for particular... 

In 1961 Marshall Nirenberg and Heinrich Matthaei reported the first breakthrough. They incubated synthetic polyuridylate, poly(U), with anE. coli extract, GTP, ATP, and a mixture of the 20 amino acids in 20 different tubes, each tube containing a different radioactively labeled amino acid. Because poly(U) mRNA is made up of many successive UUU triplets, it should promote the synthesis of a polypeptide containing only the amino acid encoded... 

Source Modified from Nirenberg, M. Leder, R (1964) RNA code words and protein synthesis. Science 145, 1399. 

As described in Section 27.2, initiation of protein synthesis in the cell is an elaborate process that relies on initiation codons and other signals in the mRNA. In retrospect, the experiments of Nirenberg and Khorana to identify codon function should not have worked in the absence of initiation codons. Serendipitously, experimental conditions caused the normal initiation require-... 

B147 D. M. Jerina, J. W. Daly, B. Witkop, P. Zaltzman-Nirenberg and S. Udenfriend ... 

H. Gobind Khorana and Marshall W. Nirenberg Physiology/Medicine The genetic code... 

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