NINCDS-ADRDA Association

FIGURE 32-2. Treatment algorithm for Alzheimer s disease. A. Cognitive treatment. B. Treatment of psychiatric or behavioral symptoms. AD, Alzheimer s disease MMSE, Mini Mental Status Examination NINCDS-ADRDA National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer s Disease and Related Disorders Association. (From Faulkner JD, Bartlett J, Hicks P. Alzheimer s disease. In DiPiro JT, Talbert RL, Yee GC, et al, (eds.) Pharmacotherapy A Pathophysiologic Approach. 6th ed. New York McGraw-Hill 2005 1164, with permission.)... 

Female or male 50-85 years old with a caregiver Mini Mental Status (MMS) test between 16 and 26 inclusive Clinical Dementia Rating (CDR) test inferior or equal to 1 National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer s Disease and Related Disorders Association (NINCDS/ADRDA) test positive for Alzheimer s disease Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM IV) test positive for dementia Exclusion Criteria ... 

Careful sample selection and preparation are the prerequisites for a successful analysis (Boguski and McIntosh, 2003). Postmortem brain samples for our studies were obtained from the M RC London Brain Bank for Neruodegenerative Diseases, Institute of Psychiatry. The AD patients fulfilled the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer s Disease and Related Disorders Association (NINCDS/ADRDA) criteria for probable AD (Mirra et al., 1991). A definite diagnosis of AD was performed by historical analysis of the brain samples, which was consistent with the CERAD criteria (Tierney et al., 1988). The brain regions temporal, frontal, occipital, parietal cortex, and cerebellum of patients with AD (72.3 7.6 years old) and controls (72.6 9.6 years old) (Seidl et al., 1997) were used for the studies at the protein level. The... 

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