NINCDS-ADRDA

FIGURE 32-2. Treatment algorithm for Alzheimer s disease. A. Cognitive treatment. B. Treatment of psychiatric or behavioral symptoms. AD, Alzheimer s disease MMSE, Mini Mental Status Examination NINCDS-ADRDA National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer s Disease and Related Disorders Association. (From Faulkner JD, Bartlett J, Hicks P. Alzheimer s disease. In DiPiro JT, Talbert RL, Yee GC, et al, (eds.) Pharmacotherapy A Pathophysiologic Approach. 6th ed. New York McGraw-Hill 2005 1164, with permission.)... 

NINCDS-ADRDA National Institute of Neurological and Communicative Disorders and Stroke/... 

Tierney,M. C., Fisher,R. H.,Lewis,A. J. etal.The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer s disease a clinicopathologic study of 57 cases. Neurology 38 359-364,1988. 

McKhann, G., Drachman, D., Folstein, M. et al. Clinical diagnosis of Alzheimer s disease report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer s Disease. Neurology 34 939-944,1984. 

Female or male 50-85 years old with a caregiver Mini Mental Status (MMS) test between 16 and 26 inclusive Clinical Dementia Rating (CDR) test inferior or equal to 1 National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer s Disease and Related Disorders Association (NINCDS/ADRDA) test positive for Alzheimer s disease Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM IV) test positive for dementia Exclusion Criteria ... 

Varma AR, Snowden JS, Lloyd JJ, Talbot PR, Mann DM, Neary D. (1999). Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer s disease and frontotemporal dementia. J Neurol Neurosurg Psychiatry. 66(2) 184-88. 

Careful sample selection and preparation are the prerequisites for a successful analysis (Boguski and McIntosh, 2003). Postmortem brain samples for our studies were obtained from the M RC London Brain Bank for Neruodegenerative Diseases, Institute of Psychiatry. The AD patients fulfilled the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer s Disease and Related Disorders Association (NINCDS/ADRDA) criteria for probable AD (Mirra et al., 1991). A definite diagnosis of AD was performed by historical analysis of the brain samples, which was consistent with the CERAD criteria (Tierney et al., 1988). The brain regions temporal, frontal, occipital, parietal cortex, and cerebellum of patients with AD (72.3 7.6 years old) and controls (72.6 9.6 years old) (Seidl et al., 1997) were used for the studies at the protein level. The... 

TABLE 63—3. NINCDS-ADRDA Criteria and Diagnostic Work-Up... 

Dubois, B., H. H. Feldman, C. Jacova et al. Research criteria for the diagnosis of Alzheimer s disease Revising the NINCDS-ADRDA criteria. I icetNeur 6(8), 2007 734—46. 

Unless histological proof is obtained, diagnosis is a question of probability. The NINCDS-ADRDA [4] criteria are usually used for diagnosis with good sensitivity (above 90%) but with low specificity, particularly in early stages (about 70%). 

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