Nidus

Once formed, crystals can interact with or adhere to other components. Adhesion can occur directly between crystals to form larger structures which may act as the nidus for further mineralization. Crystals can also interact with metabolites and/or tissues to form such structures. These interactions can and do alter the stereochemical course of crystal assembly, and molecular recognition probably accounts for the striations and intricate geometries adopted by biomineralized structures. The role and composition of metabolites comprising the matrix may be useful to understanding the local and large-scale structure of biominerals. 

An alternative to thiazides is allopurinol. Some studies indicate that hyperuricosuria is associated with idiopathic hypercalcemia and that a small nidus of urate crystals could lead to the calcium oxalate stone formation characteristic of idiopathic hypercalcemia. Allopurinol, 300 mg daily, may reduce stone formation by reducing uric acid excretion. 

Grivell, A.R. Jackson, J.F. Thymidine phosphotransferase and nucleotide phosphohydrolase of the fern Asplenium nidus. General properties and inhibition by adenosine 3 5-cyclic monophosphate. Biochem. J., 155, 571-581 (1976)... 

Lithium hydroxide monohydrate. CAS l3IO-65-2. LiOH H 0 loses water at I0LC. LiOH nidus at 450 C. The compound is soluble in water. The compound is used in the formulation of lithium soaps used in multipurpose greases also in the manufacture of various lithium salts and as an additive lo the electrolyte of alkaline storage bailerics. LiOH also is an efficient, light-weight absorbent for carbon dioxide. 

Urinary calculi are frequent concomitants of vitamin A deficiency. The epithelium of the urinary tract shares in the general pathological changes of all epithelial structures. Epithelial debris thus may provide the nidus around which a calculus is formed. Abnormalities of reproduction include impairment of spermatogenesis, degeneration of testes, abortion, resorption of fetuses, and production of malformed offspring. 

A red thrombus can form around a white thrombus as mentioned above or de novo in low-pressure veins, initially by adherence of platelets (as in arteries) but followed promptly by the process of blood coagulation so that the bulk of the thrombus forms a long tail consisting of a fibrin network in which red cells are enmeshed. These tails become detached easily and travel as emboli to the pulmonary arteries. Such emboli often arise from a deep venous thrombosis (DVT)—a thrombus in the veins of the legs or pelvis. Although all thrombi are mixed, the platelet nidus dominates the arterial thrombus and the fibrin tail the venous thrombus. Arterial thrombi cause serious disease by producing local occlusive ischemia venous thrombi, by giving rise to distant embolization. 

In spinal vascular malformations abnormally thick, often tortuous vessels on the surface of the spinal cord can be identified as well as the angiomalike nidus of the AVM. MRI facilitates the differentiation between SDAVF and intramedullary AVM. 

AVMs of the glomerular type are more frequent and characterized by a nidus similar to those of most cerebral AVMs. They may be located superficially on the surface of the spinal cord or deep within the cord parenchyma or extend to both compartments. Due to the numerous anastomoses between the spinal cord arteries, the nidus is always supplied by several arteries or branches derived from the anterior... 

Partial or complete replacement of natural organs with prosthetic components will someday be commonplace. For instance, the design of the total artificial heart, which has had limited clinical success, involved an application of many fundamental principles already discussed as they relate to hemodynamics, biomaterials, and control. Most would agree, however, that the materials-blood-tissue interface is the nidus for some of the most serious problems preventing the development of a safe and reliable artificial heart. This reinforces the importance of investigating at the molecular level the complex interactions that occur between artificial surfaces and the physiological environment. 

The authors speculated that cocaine may have caused aortic inflammation by assuming that cocaine-related increased sympathetic tone along with possible cocaine-related aortic inflammation (similar to reported cases of cocaine-related vascular injury) may have led to enhance aggregation of platelets at the inflamed area, which would act as a nidus to form a thrombus. The thrombus resolved with anticoagulation within 13 days and similar results have been reported before (81). The patient had very high creatine kinase activity, suggesting rhabdomyolysis, which could have been caused by intense cocaine-related vasoconstriction. 

We have recently found an additional amino-terminal-truncated A(3 peptide, i.e., A 52-42 in CSF of patients with AD (Wiltfang et al., 2001a), and this peptide is the second most abundant A 5 peptide in the frontal lobe of patients with AD, after A 5l-42. In the CSF, it is present in a subset of 35% of AD cases. Experimental studies with knock-out mice showed that A 52-42 was most probably produced by an alternative (3-secretase cut, and of particular pathophysiological importance is that this peptide may serve as a first nidus for 5-amyloid plaque formation (Wiltfang et al., 2001a). 

The authors pointed out that nelfinavir is normally only 1-2% excreted in the urine, and they postulated that the indinavir may have started a nidus on which the nelfinavir was subsequently deposited. 

Nidus BD, Field M, Rammelkamp CH Jr. Salivary gland enlargement caused by sulfisoxazole. Ann Intern Med 1965 63(4) 663-5. 

Galls . Galls. Quercus cerris. W. IV. 404. Cyniphis nidus. The nest of Cynips Quercifolii. 

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