Nickel in Biology

Cammack, R. Catalysis by Nickel in Biological Systems Marcel Dekker New York, 1993. 

Analytical methods for detection of nickel in biological materials and water include various spectrometric, photometric, chromatographic, polarographic, and voltametric procedures (Sunder-man et al. 1984 WHO 1991). Detection limits for the most sensitive procedures — depending on sample pretreatment, and extraction and enrichment procedures — were 0.7 to 1.0 ng/L in liquids, 0.01 to 0.2 pg/m3 in air, 1 to 100 ng/kg in most biological materials, and 12 pg/kg in hair (WHO 1991 Chau and Kulikovsky-Cordeiro 1995). 

Cammack, R. and van Vliet, P. (1999) Catalysis by Nickel in Biological Systems. In J. Reedijk and E. Bouwman (eds). Bioinorganic Catalysis, 2nd edn. New York Marcel Dekker, pp. 231-68. 

Analytical Methods for Determining Nickel in Biological Samples... 

Analytical methods and detection limits for nickel in biological materials are reported in Table 6-1. The presence of nickel in other biological materials such as hair and nails can be determined by the same analytical techniques used for blood and tissue after suitable procedures for dissolving the sample have been utilized (Stoeppler 1980 Takagi et al. 1986, 1988). 

The Nickel Producers Environmental Research Association (NiPERA) is sponsoring research on the application of inductively coupled plasma-mass spectroscopy (ICP-MS) to isotopic analysis of nickel in biological samples, on the development of sampling instrumentation for assessing workers exposure to nickel in the nickel industry, and on methods for utilizing newly developed analytical methods, such as laser beam ionization mass spectrometry, for the identification and speciation of nickel compounds in powders and dusts with particular reference to nickel refining. 

Stoeppler M. 1980. Analysis of nickel in biological material and natural waters. In Nriagu JO, ed. Nickel in the environment. New York, NY John Wiley and Sons, Inc., 661-821. 

Sunderman, F.W., Jr. Measurements of Nickel in Biological Materials by Atomic Absorption Spectrometry, Amer. J. Clin. Path., 44, 182 (1965). 

Ivanova E, Benkhedda K and Adams F (1998) Determination of copper, manganese and nickel in biological samples and sea-water by flow injection on-line sorption preconcentration in a knotted reactor coupled with electrothermal atomic absorption spectrometry. J Anal Atom Spectrom 13 527—531. 

Aggarawal, S.K., Kinter, M., Wills. M.R., Savory, J. and Herold, D.A. (1989). Isotope dilution gas chromatography/mass spectrometry for the determination of nickel in biological materials. Anal. Chem. 61,1099-1103. 

Bern, H., Holzbecher, J. and Ryan, D.E. (1983). Determination of nickel in biological materials and sea water by neutron activation and liquid scintillation counting of nickel-65. Anal. Chim. Acta 152, 247-255. 

Stoeppler. M., 1983. General analytical aspects of the determination of lead, cadmium, and nickel in biological fluids. In Facchetti, S. (Ed.), Analytical Techniques for Heavy Metals in Biological Fluids. Elsevier, Amsterdam. 

Analytical methods used in the determination of nickel in biological materials are the same as those used for environmental samples. Nickel is normally present at very low levels in biological samples. Atomic absorption spectrometry (AAS) and inductively coupled plasma-... 

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