Nicholls, Mark

Figure 30-13 Section through a rat brain. This brain, which has been very widely used in neurochemical studies, appears superficially to be quite different from the human brain (Fig. 30-1), which is characterized by its large cerebral cortex. However, basic pathways are the same. Some major pathways for glutamate-secreting (glutamatergic) neurons are marked by arrows. Most of these originate in the neocortex (outer layers of the cerebral cortex) and the hippocampus. From Nicholls.149 Courtesy of David G. Nicholls.

BILL CARROLL and JOHN J. NICHOLS Olin Corp., P.O. Box 222, St. Marks, FL 32355... 

Marked interference with mitochondrial function is a feature of HD brain (Browne and Beal, 2004 Browne et al., 1997 Browne, 2008 Nicholls, 2009 Reddy et al., 2009 Quintanilla and Johnson, 2009 Su et al., 2010). For example, Browne et al. (1997) showed that citrate synthase-corrected complex II-III activity is markedly reduced in both HD caudate (-29%) and putamen (-67%), and complex IV specific activity is reduced in HD putamen (-62%). Tabrizi et al. (1999) reported that aconi-tase specific activity is reduced to 8,27, and 52% of control activities in HD caudate, putamen, and cerebral cortex, respectively. Tabrizi et al. (2000) also reported that aconitase and complex IV activities are decreased in the striatum of 12-wk HD transgenic (R6/2) mice, and complex IV activity is decreased in cerebral cortex. As noted previously for human HD, oxidative stress indicators (increased inducible NO... 

King, C., Moore, N., Marks, R., and Nicholls, S. Preliminary studies into percomeal penetration and elemental content of the stratum comeum using x-ray microanalysis. Arch. Derm. Res. 265 257-265, 1978. 

Since it was shown by Cannon et al. [23] that ADP acted from the outside of the mitochondria to induce respiratory control, a specific site of interaction could be envisaged. Such a site was characterized by Nicholls [33] by binding of [ H]GDP. Further, by labelling brown fat mitochondria with [ P]azido-ATP, Heaton et al. [34] demonstrated that — besides the ATP/ADP-translocase at 30 kDa — a specific band with a molecular weight of 32000 was labelled, and this was identical with the GDP-binding site. This protein (i.e., thermogenin) had already been observed by Ricquier and Kader as the only protein the concentration of which was markedly altered in brown fat mitochondria isolated from cold-acclimated animals [35] (Fig. 10.8). 

In his report to the Convention of 1960, however. Secretary Adley B. Nichols stated The distribution picture of the USP in Spanish has not been satisfactory for some time, and this is especially the case with USP XV. In no country is there a marked demand for the translation. Apparently the English language is sufficiently widely known today to permit the use of the readily available English edition. Perhaps the best summary of why the USP produced a Spanish edition of the pharmacopeia can be found in the words of Dr. Charles H. LaWall, Chairman of the Committee of Revision The publication of the Spanish edition can never be considered financially advantageous to the convention, but it should be continued as a patriotic duty and in recognition of the in-use of the book in the Spanish-speaking American countries. ... 

Griffits, W., Mark, D., Marshall, I., Nichols, A., 1998. Aerosol Particle Size Analysis. Royal Society of Chemistry, Cambridge, UK, pp. 116. 

The characteristic fatty acid patterns of plant triacylglycerols are to some extent under genetic control (see Section VI). In addition, environmental factors may modify the basic patterns, the extent of modification depending on the species. Thus the seed oils of plants grown in cool climates tend to be more unsaturated than those grown in warm climates (Hitchcock and Nichols, 1971). The chief influence seems to be on the characteristic fatty acid of the seed, so that for example in flaxseed oil there is a marked decline in the proportion of linolenic acid between 10° and 30°C and a corresponding increase in the proportion of its precursor, oleic acid (Canvin, 1965). Similarly, the proportion of linoleic acid in sunflower seed oil steadily declines between 10° and 30°C, to be replaced by oleic acid. Yet the linoleic content of safflower and the ricinoleic acid of castor are unaffected by the same variation in temperature (Canvin, 1965). All rules have exceptions, and the experiments of Appelqvist (1975) showed that different lines of zero-erucic acid rape could respond differently to the same climatic variations. 

Figure 10.8 SNIFTIR difference spectra for Pt(l 10) in 1 M HClO.,. E, = 650 mV and E2 as marked (versus RHE). Reprinted from Ref. 118] R.J. Nichols, PhD thesis. University of...

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