Niche drugs

And after all that, after struggling through those years of decoding and genomics research, what kind of product would the pharmaceutical labs end up with Most likely a narrowly targeted niche drug that wouldn t make much money. 

Pharmaceutical and medical device supply chains Niche drugs — restructuring the pharmaceutical supply chain for small batch production, shorter patiart life... 

Antidepressants Desipramine, imipramine, sertraline, fluoxetine, paroxetine, venlafaxine, bupropion, nefazodone, mirtazapine, gepirone, amineptine Mixed findings suggest that better designed studies may find a niche for some of these drugs. Amineptine was effective for withdrawal symptoms. 

Examples abound regarding the role of serendipity in the discovery of new therapeutic approaches, which on closer examination usually turned out to be the result of clinicians paying attention to unexpected clinical effects rather than discounting them. For example, lithium was tried first for hypertension, chlorpro-mazine was initially developed as an anesthetic, and imipramine was originally regarded as an antihistamine and an antipsychotic agent. Without astute clinical observations, these drugs would not have found their niche, nor would clozapine have been revived for the benefit of millions of the most difficult to treat schizophrenic patients. Other examples include the expanded indications of newer... 

SNPs), 34, 39, 52, 211, 305. See also SNP entries patenting, 114—116 6-Mercaptopurine, 208-209 Small-niche market, 130 Small population groups, drug production for, 285-286 SNP Consortium, 34, 40, 83, 94,126, 127... 

Frantz, S. (2006) Pipeline problems are increasing the urge to merge. Nature Reviews. Drug Discovery, 5, 977-979. Owens, J. (2007) 2006 drug approvals finding the niche. Nature Reviews. Drug Discovery, 6, 99-101. 

Combined with the trend of small niche companies in drug development has come the parallel corporate trend of downsizing and the hesitancy to expand divisions to take on temporary projects. A great number of large companies are contracting for critical aspects of drug discovery and development. Compounds can be manufactured xmder contract. 

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