Niacinate

Chemical Name Myo-lnositol hexa-3-pyridine carboxylate Common Name Inositol hexanicotinate Structural Formula  

Trada Nama Manufacturer Country Year Introduced 

Nicotinic acid Phosphorus oxychloride meso-lnositol 

100 g of nicotinic acid were suspended in 265 ml of distilled and dried pyridine without stirring. 68 g of phosphorus oxychloride were added dropwise to this mixture under continual stirring. The temperature of the reactants, initially at 20°C,wasallowed to rise to about 60°C, and this temperature was maintained for a further 60 minutes. Thereafter 24.5 g of meso-inositol were added gradually, the temperature being controlled so that it did not exceed about 80°C. The reactants were maintained at this temperature for from 2 to 3 hours, and thereafter the reaction mixture was poured into 500 ml of water. The pyridine salts formed during the reaction readily dissolved, and the meso-inositol hexanicotinate which had formed crystallized out. The ester was filtered off and washed with water and acetone or alcohol. Finally, the meso-inositol hexanicotinate was dried at 100°C. 

Chemical Name Complex polypeptide hormone with molecular weight over 6,000 see Structural Formula 

Chemical Name 3-Pyridine carboxylic acid compounded with 3,7 Jihydro-7-(2-hydroxy-3-[(2-hydroxymethyl)methylamino] propyl] -1,3-dimethyl-1 H-purine-2,6-dione(1 1) 

To a well-stirred solution of 740 parts by weight of epichlorohydrin in 200 parts by voiume of isopropyl alcohol are added 600 parts by weight of methy iaminoethanoi during about 3 

For purpose of purification, the hot alcoholic solution is mixed with 975 parts by weight of nicotinic acid while being stirred and heated until the nicotinic acid is completely dissolved. 

The 3-(methylhydroxyethylamino)-2-hydroxypropyltheophylline-nicotinate separates, while still being warm, in the form of shiny, thin, small sheets. After cooling, the crystallization product is sucked off from the mother liquor and recrystallized from 85% isopropyl alcohol. 

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Pellagra is a disease caused by a deficiency of niacm (C6FI5NO2) in the diet Niacin can be synthesized in the laboratory by the side chain oxidation of 3 methylpyndine with chromic acid or potassium permanganate Suggest a reasonable structure for niacin... 

VITAT S - NIACINE,NICOTINAMIDEAND NICOTINIC ACID] (Vol25)... 

Vitamin B3. See Vitamins, Niacin, Nicotinamide, and Nicotinic acid. 

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