New drug delivery systems

New drug delivery systems are of great scientific and commercial interest. Amphiphilic networks composed of about 50/50 hydrophobic PIB and hydrophilic poly(2-(-dimethylamino)ethyl methacrylate) (DMAEMA) polymer segments were found to be biocompatible and to a large extent avascular (7). These PHM-PDMAEMA networks (i, in line with propositions of Weber and Stadler (2), and Sperling (J), denotes PDMAEMA chains linked by PIB chains) gave pH dependent... 

New regulations Accelerating development of cancer chemotherapy New drug-delivery systems... 

SD Alani, W Hammerstein. (1990). The ophthalmic rod—A new drug delivery system. II. Graefes Arch Clin Exp Ophthalmol 228 302-304. 

The Ca2+ -responsive conformationally changeable membrane may be a good model of a new drug-delivery system, where calcitonin or parathyloid hormone can be released for the homeostasis of serum Ca2+ level. 

NeubergerT, Schopf B, Hofmann H, Hofmann M, von Rechenberg B (2005) Superparamagnetic nanoparticles for biomedical applications possibilities and limitations of a new drug delivery system. Journal of Magnetism and Magnetic Materials 293 483 196. 

Kilts CD. Potential new drug delivery systems for antidepressants an overview. J Clin Psychiatry. 2003 64(suppl 18) 31—33. 

Suzuki Y, Tanihara M, Nishimura Y et al. (1998) A new drug delivery system with controlled release of antibiotic only in the presence of infection. J Biomed Mater Res 42 112-116... 

In the last few decades, the discovery of SPs from natural sources with potent antiviral activities has increased significantly, but their clinical application against human viral infections is still far from being satisfactory. The therapeutic perspectives of SPs will probably improve with an adequate formulation in a clinically useful vehicle. The development of new drug delivery systems, such as encapsulation in liposomes or nanoparticles, is a strategy currently gaining attention to improve the in vivo effectiveness and reduce the adverse effects of polysulfates. The potential of these natural compounds to prevent a wide spectrum of severe viral diseases warrants further investigation to ameliorate their administration in systemic virus infections. 

Kayser, O., Lemke, A., and Hernandez-Trejo, N. (2005),The impact of nanobiotechnolgy on the development of new drug delivery systems, Curr. Pharm. Biotechnol., 6, 3-5. 

RECOMBINANT SACCHAROMYCES CEREVISIAE AS NEW DRUG DELIVERY SYSTEM TO GUT IN VITRO VALIDATION AND ORAL FORMULATION... 

Blanquet, S., Antonelli, R., Laforet, L., Denis, S., Marol-Bonnin, S., and Alric, M. (2004), Living recombinant Saccharomyces cerevisiae secreting proteins or peptides as a new drug delivery system in the gut, J. Biotechnol., 110, 37-49. 

Although conventional eye drops still represent about 90% of all marketed ophthalmic dosage forms, there have been significant efforts towards the development of new drug delivery systems. 

Monique Alric, Universite d Auvergne, Clermont-Ferrand, France, Recombinant Saccharomyces Cerevisiae as New Drug Delivery System to Gut In Vitro Validation and Oral Formulation... 

Cellular reservoirs and anatomical sanctuary sites, such as the CNS, hamper HTV-l treatment and allow HTV-l to persist. To these ends, the SCID mouse model was modified to allow spread of HTV-1 infection betw een human MDM in mouse brain tissue behind an intact BBB. This model permitted comparative assessment of different anti-retroviral drugs by measurements of viral load and numbers of infected human macrophages (Limoges et al., 2000 Limoges et al., 2001). New drug delivery systems across the BBB and novel neuropro tec five therapeutics are under investigation (Persidsky et al., 2001 Dou et al., 2003 Dou et al., 2005). 

Pharmaceutical compositions of the new compound or new improved formulations of existing compounds are also patentable. For a new drug-delivery system, patent protection can be very important and useful, especially if developed for the delivery of an existing product. 

NDA is required for new drug delivery systems or formulations (e.g., sustained release formulation)... 

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