New Developments in the Context of Clean Synthesis

It is still true to say that zeolites have found relatively Httle use in the liquid phase synthesis of organic compounds due to their small pore size and related 

Owing to their numerous applications as fine chemicals for the synthesis of bioactive compounds such as pesticides and pharmaceuticals, isomerically pure chloroaromatics are very valuable materials. /-Butyl hypochlorite/HNa fauja-site in acetonitrile represents an efficient and highly regioselective system of mono-chlorination of a wide range of mono- and disubstituted aromatic substrates in mild conditions (Reaction S). 

Partially protonated faujasite X is far superior to amorphous silicas and to other zeolites in terms of efficiency and regioselectivity (Table 2.3). Advantages of /-butyl hypochlorite over other chlorinating reagents have been demonstrated.41 The methodology is applicable to a range of substituted benzenes with 

Substituent Product yield (%) para/ortho chlorination ratio 

Friedel-Crafts reactions continue to represent one of the greatest challenges for clean synthesis. They are widely used to manufacture an enormous range of important chemical products and intermediates, ketones being among the most important with applications in pharmaceutical and agrochemical products, flavours and fragrances. Traditional methods of manufacture are based on 

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