Neurotrophic properties

It has beat proposed that possible mechanisms underlying the neuroprotective and/or neurotrophic properties of EGb in the CNS indude influences on neurotransmitters, energy metabolism and membrane functions, as well as antioxidant activities and inhibition of platelet-activation factor (PAF). 

The 2,2-dimethylbicyclo[3.3.1]nonan-9-one scaffold exemplified by structure 3.25 (Fig. 3.16) is the core structural motif of several natural products (e.g. 3.26 and 3.27, Fig. 3.16) with, among others, strong neurotrophic properties ... 

Following the discovery that nonimmunosuppressive immunophilin ligands retained the neurotrophic properties of FK506, a number of compounds have been evaluated for efficacy in several animal models of neurodegenerative disorders. FK506 had already been shown to promote recovery of damaged peripheral nerves several reports now detail the ability of compounds in Tables 4 and 5 to promote regeneration of both central and peripheral neurons. 

Using the three-chamber tissue culture system (Campenot, 1977) we tested the neurotrophic properties of ACTH 4-10, Org 2766 and BIM 22015 on dissociated, mixed cells of the spinal... 

L., Zhong, W., Xiao, J., Hu, Y., Li, S. (2006) FK506-binding protein ligands structure-based design, synthesis, and neurotrophic/neuroprotective properties of substituted 5,5-dimethyl-2-(4-thiazolidine)carboxylates. / Med Chem 49, 4059 071. 

After these pioneering works, several reviews cover the enormous number of papers published in this field [3-7]. The synthesis of oxetanes can have a great importance in the development of compounds with relevant biological properties oxetane ring is present in the skeleton of taxol (1), an important drug used in the treatment of ovarian cancer [8] in merrilactone A (2), a new sesquiterpene dilactone with neurotrophic activity [9] and in several antiviral oxetanes, such as 3, 4, and 5, which have been described in literature (Scheme 3.2) [10-12],... 

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