Neurospora crassa strain

Figure 8.28 Changes in the content of PolyP fractions during growth of Neurospora crassa strains ad-6 (parent strain) and 30,19-3 (a leaky mutant in exopolyphosphatase), and a slime mutant devoid of the cell envelope (Trilisenko et al., 1980 1982a,b) (o) growth ( ) PolyP content in different fractions.

L. V. Trilisenko, V. M. Vagabov and I. S. Kulaev (1982a). Comparative study of some properties of polyphosphate phosphohydrolase in Neurospora crassa strain ad-6 (28610) and a leaky derivative. 

DE 019 bucillamine, deacetyllanatoside C deslanoside, deanol [ban] (norcholine N-dimethylethanolamine) is isolated from a Neurospora crassa strain and is a residue present in the alkaloids cassaine and cassaidine. It is a choline precursor and has been used to enhance central acetylcholine formation. It has been used as a CNS STIMULANT (nootropic agent) to enhance mental function, and as an ANTIDEPRESSANT,... 

Goldie, A.H. and Subden, R.E., The neutral carotenoids of wild-type and mutant strains of Neurospora crassa, Biochem. Genet. 10, 275, 1973. 

Purification and characterisation of galactose-induced pectinases from the exo-1 mutant strain of Neurospora crassa... 

Sargent ML, Briggs WR, Woodward DO 1966 Circadian nature of a rhythm expressed by an invertaseless strain of Neurospora crassa. Plant Physiol 41 1343—1349 Selby CP, Thompson C, Schmitz TM, Van Gelder RN, Sancar A 2000 Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice. Proc Natl Acad Sci USA 97 14697-14702... 

Light is a major regulatory influence on carotenoid synthesis in many plant and microbial systems. A review of this photoregulation has been published. Other papers report the photoinduction of the biosynthesis of phytoene and other carotenoids in strains of Neurospora crassa. " ... 

Mutation Neurospora crassa Reversion of adenine auxo-trophy in strains N23 and N24 Gene mutations <1 mo L L S NA... 

Fig. 1 Blocks of multiple sequence alignment of protein sequences of carboxypeptidases from B. taurus, Mus musculus, Rattus norvegicus, Neurospora crassa, Schizosaccharomyces pombe, Drosophila melanogaster, and Homo sapiens along with protein sequence from H. pylori (Uniprot accession code HPAG1 0372 from strain HPAG1). Numbers on the top correspond to amino acid residue number of the carboxypeptidase enzyme from B. taurus. Gray vertical columns indicate conserved residues. Amino acid residues corresponding to Glu-182 and His-306, which coordinate to zinc, are conserved, whereas another Zn-coordinating amino acid residue corresponding to His-179 is substituted by Gin in the Helicobacter sequence. Functionally important residues corresponding to Arg-237 are also conserved...

Regnery, D. C. a Leucineless Mutant Strain of Neurospora crassa. J. biol. 

The existence of a mitochondrial pathway for de novo fatty acid synthesis was first reported 50 years ago, when it was generally assumed that fatty acid synthesis proceeded by reversal of the mitochondrial pathway for fatty acid P-oxidation (F. Lynen, 1957). However, the discovery of the cytosolic malonyl-CoA pathway (R.O. Brady, 1958 S.J Wakil, 1958) casted doubt on these claims and interest in this system waned until the discovery that mitochondria of both Neurospora crassa and Saccharomyces cerevisiae contain nuclear-encoded mitochondrial proteins that function as a type II FAS system. Disruption of the genes encoding these enzymes in both N. crassa and S. cerevisiae produces respiratory-deficient phenotypes and in S. cerevisiae cellular lipoic acid is reduced to less than 10% of that of the wild-type strain (R. Schneider, 1995 E. Schweizer, 1997). These observations suggested that in fungi one of the roles of this pathway might be to generate the lipoyl moieties required for mitochondrial function. 

Antidote Activity of Emodin (18) Against Diethofencarb (15) in an MBC Resistant Strain qf Neurospora crassa... 

We thank Professors R. Yokosawa, F. Tomita, and M. Fujimura for kindly supplying the fungal strains, Aphanomyces cochlioides, Cladosporium herbarum, and Neurospora crassa, respectively. Much of the research on which this review is based, has been carried out by the following students, Masters Y. Matsukura, N. Toda, and H. Katsuta (benzimidazole antidotes), and by Dr. T. Horio Masters T. Takayama, H. Kikuchi, K. Ohkawa, and M. Mizutani (zoospore attractants). 

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