Neurophysin 8-arginine vasopressin

The gene for arginine vasopressin is that of a 166-residue precursor protein carrying a 19-residue signal sequence at the N terminus.84 This sequence is followed by that of vasopressin, then after a GKR linker by the 95-residue neurophysin II. Finally, after one additional arginine there is a 39-residue glycopeptide. Oxytocin originates in a parallel way from its own precursor.85... 

Anti-diuretic hormone (arginine vasopressin) is a nine-amino-acid peptide secreted from the posterior pituitary. Within hypothalamic neurons, the hormone is packaged in secretory vesicles together with a carrier protein called neurophysin both are released upon secretion. 

Neurophysins small proteins associated with the hormones oxytocin and vasopressin. In bovines, oxytocin-like arginine vasopressin and N.n are synthesized from a single polypeptide precursor, as are oxytocin and N. I. Most species have more than two N., but usually there are two major N.The middle sequence of N. is conserved, and the N. differ in their terminal sequences. The N. bind to the neurohormones with which they are synthesized and are secreted with them into the blood. The biological function, if any, of the N. is not known. [H. Land et al. Nature 302 (1983) 342-344 A. G. Robinson in D.T. Krieger J.C Hughes (eds.) Neuroendocrinology (Sinauer Assoc., Sunderland, Mass., 1980)]... 

CRYSTALLINE COMPLEXES OF NEUROPHYSIN-I AND -II WITH 8-ARGININE VASOPRESSIN... 

II and -M. The number of moles of vasopressin bound per mole of any one of the three proteins was reduced in the presence of oxytocin. This is almost certainly because of a competition for certain peptide binding sites by oxytocin. It is interesting to note that the non-mammalian hormone 8-arginine vasotocin is bound by mammalian neurophysin In addition, Breslow... 

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