Neuron defective, selection

In model-1 (Fig. 1), which provides the mechanism of AR-JP, cumulative increases of a putative parkin substrate(s), provisionally termed X(s), which has yet to be identified, cause selective neuronal death. In this model, the target X protein is simply considered as a factor whose accumulation directly mediates death of dopaminergic neurons i.e., abnormal accumulation of X forcibly evokes cell death. To explain that genetic defect of the parkin gene causes specifically dopaminergic neuronal... 

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