Neuromuscular blocking agents paralysis induced

The muscle-paralyzingcurare alkaloids are quaternary salts that are not absorbed when taken orally. For surgical procedures they must be administered by intravenous injection, which results in onset of paralysis in at most a few minutes anesthesia is normally induced before administration of the muscle relaxant (44), which is followed by artificial respiration. Although the neuromuscular blocking agents are potentially lethal when administered alone, in the environment of an operating theater they are truly life-saving... 

Pyrantel is a depolarizing neuromuscular blocking agent that opens nonselective cation channels and induces marked, persistent activation of nicotinic acetylcholine receptors, which results in spastic paralysis of the worm. Pyrantel is effective against hookworm, pinworm, and roundworm unlike its analog oxantel, it is ineffective against Trichuris trichiura. 

If the patient is not fuiiy relaxed (eg, if the jaw is not flaccid or neck mobility Is restricted), induce neuromuscular paralysis with succinyl-choline (1-1.5 mg/kg intravenously [IV]), rocuronium (0.6-1.2 mg/kg IV) or pancuronium (0.1 mg/kg IV), or another neuromuscular blocking agent (see p 472). Caution In children, succinylcholine may induce excessive vagal tone, resulting in bradycardia or asystole. Patients with digitalis intoxication (see p 155) may have a similar response to succinylcholine. Pretreat with atropine (0.01 mg/kg IV),... 

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