Neuromuscular blocking agent interaction

Marshall IG. Pharmacological effects of neuromuscular blocking agents interaction with choUnoceptors other than nicotinic receptors of the neuromuscular junction. Anest Rianim 1986 27 19. 

Drugs that may interact with capreomycin include aminoglycosides and nondepolarizing neuromuscular blocking agents. 

Drug Interactions Other antihypertensive agents Carbamazepine (vasodilators, ACE inhibitors, Rifampin diuretics, and beta-blockers) Phenobarbital Digoxin Cyclosporine Disopyramide Theophylline Flecainide Inhalation anesthetics Quinidine Neuromuscular blocking agents Cimetidine Lithium ... 

Wali FA. Myorelaxant effect of diazepam. Interactions with neuromuscular blocking agents and cholinergic drugs. Acta Anaesthesiol Scand 1985 29(8) 785-9. 

The potential for interactions between donepezil and neuromuscular blocking agents has major implications for the anesthetic care of people taking donepezil (81,82,83). Prolonged paralysis resulting from an interaction of donepezil with suxamethonium has been reported (84,85). 

This latter method has the advantage that neuromuscular blocking agents are not required since air is not being forcefully pumped into the lungs. This allows the spontaneous breathing of the animal to be used to study both bronchoconstrictors and bronchodilators, as well as allowing interactions of these compounds to be studied. 

Interactions. Morphine (also pethidine and possibly other opioids) is potentiated by monoamine oxidase inhibitors. Any central nervous system depressant (including alcohol) will have additive effects. Patients recently exposed to neuromuscular blocking agents (unless this is adequately reversed, e.g. by neostigmine) are particularly at risk from the respiratory depressant effects of morphine. The effect of diuretic drugs may be reduced by release of antidiuretic hormone by morphine. Useful interactions include the potientating effect on pain relief of tricyclic antidepressants and of dexamfetamine. 

From animal experiments (8) it seems hkely that drug interactions with atracurium will be similar to those for other non-depolarizing neuromuscular blocking agents. Laudanosine has been reported to increase the MAC for halothane in animals (61). 

Singh YN, Marshall IG, Harvey AL. The mechanisms of the muscle paralysing actions of antibiotics and their interaction with neuromuscular blocking agents. Rev Drng Metab Drug Interact 1980 3 129. 

Amaki Y, Nagashima H, Radnay PA, Foldes FF. Ketamine interaction with neuromuscular blocking agents in the phrenic nerve-hemidiaphragm preparation of the rat. Anesth Analg 1978 57(2) 238 3. 

Ghoneim MM, Long JP. The interaction between magnesium and other neuromuscular blocking agents. Anesthesiology 1970 32(l) 23-7. 

Maestrone E. Interaction of neuromuscular blocking agents in surgical patients. In Agoston S, Bowman WC, editors. Monographs in Anaesthesiology.. Amsterdam Elsevier Science Pubhshers BV, 1990 19 199. 

Clinically important, potentially hazardous interactions with aminoglycosides, non-depolarizing neuromuscular blocking agents... 

Swen J, Rashkovsky OM, Ket JM, Koot HWJ, Hermans J, Agostmi S. Interaction between nondepolarizing neuromuscular blocking agents and inhalational anesthetics. Anesfh Analg (1989) 69, 752-5. 

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