Neuromuscular block aminoglycosides

Aminoglycosides Neuromuscular blocking agents Additive adverse effects Avoid... 

Drugs that may interact with capreomycin include aminoglycosides and nondepolarizing neuromuscular blocking agents. 

WARNING Systemic absorption of oral route may cause neuro/oto/nephrotox may result resp paralysis possible w/ any route of administration Uses Hepatic coma, bowel prq) Action Aminoglycoside, poorly absorbed PO -1- GI bacterial flora Dose Adults. 3-12 g/24- h PO in 3-4 doses Peds. 50-1 (X) mg/kg/24 h PO in 3-4 doses Caution [C, /-] Renal failure, neuromuscular disorders, hearing impair Contra Intestinal obst Disp Tabs, PO soln SE Hearing loss w/ long-term use rash, NA EMS Use neuromuscular blockers w/ caution, reduced dose may be necessary t bleeding risk w/ concurrent anticoagulant use OD May cause neuromuscular block and kidney failure calcium salts can be used to revise neuromuscular block... 

C) Aminoglycosides cause a neuromuscular block by displacing Ca" + from the neuromuscular junction. 

Toxic effects, which depends on dose and duration of treatment, mainly manifest as ototoxicity. Aminoglycosides also may cause nephrotoxicity and are reversible if they are withdrawn. They are known to cause neuromuscular blockade hence, care is necessary when used along with neuromuscular-blocking agents. Other reactions include allergy and cross-reactivity infections, as well as... 

Myasthenia gravis is made worse by quinine and quinidine and myasthenics are intolerant of competitive neuromuscular blocking agents and aminoglycoside antibiotics. 

Antibiotics aminoglycosides, e.g. neomycin, gentamicin, potentiate neuromuscular blocking drugs. 

Like the other aminoglycosides, kanamycin has neuromuscular blocking properties, particularly if given directly into the peritoneum (1). However, it seems to be less dangerous in this respect than neomycin or streptomycin. 

Clindamycin, either alone or in combination with neuromuscular blocking drugs or aminoglycosides, has been associated with neuromuscular blockade. 

Molgo J, Lemeignan M, Thesleff S (1987) Aminoglycosides and 3,4-diamino-pyridine on neuromuscular block caused by botulinum type A toxin. Muscle Nerve. 10 464-70. 

Clinically important, potentially hazardous interactions with aminoglycosides, non-depolarizing neuromuscular blocking agents... 

The neuromuscular blocking effects of depolarizing and nondepolarizing agents are enhanced by aminoglycosides, and prolonged respiratory depression may occur. 

Aminoglycoside antibiotics produce neuromuscular blockade by inhibiting ACh release from the preganglionic terminal (through competition with Ca ) and to a lesser extent by noncompetitively blocking the receptor. Tetracyclines also can produce neuromuscular blockade, possibly by chelation of Ca. Additional antibiotics that have neuromuscular blocking action, through both presynaptic... 

---