Neurological association studies

Hering, R., Petrovic, S., Mietz, E. M. et al. Extended mutation analysis and association studies of Nurrl (NR4A2) in Parkinson disease. Neurology 62 1231-1232, 2004. 

Author (year) Previous Ethnic Target studied for Neurological Association Number of patients with CIPN used for... 

Target studied for Neurological Association with CIPN used for... 

Okazaki, H., Aronson, S.M., DiMaio, D.J., Olivera, J.E., 1963. Acute lead encephalopathy of childhood histological and chemical studies with particular reference to angiopathic aspects. In Yahr, M.D. (Ed.), Transactions of the American Neurological Association, vol. 88. Springer Publishing Co., New York, pp. 248—250. 

A radiological study, Abstracts of the 1988 Annual Meeting Of the American Association of Neurological Surgeons, 1988, p. 

Brem, H., Tamargo, R. J., Finn, M., and Chasin, M., Biocompatibility of a BCNU-loaded biodegradable polymer A toxicity study in primates, Abstracts of the 1988 Annual Meeting of the American Association of Neurological Surgeons, 1988,... 

Sacktor N, Lyles RH, Skolasky R, Kleeberger C, Seines OA, Miller EN, Becker JT, Cohen B, McArthur JC (2001) HIV-associated neurologic disease incidence changes Multicenter AIDS Cohort Study, 1990-1998. Neurology 56(2) 257-260... 

Cui L, Locatelli L et al (1997) Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells. J Pharmacol Exp Ther 280(3) 1228-1234 Dal Pan GJ, Glass JD et al (1994) Clinicopathologic correlations of HIV-l-associated vacuolar myelopathy an autopsy-based case-control study. Neurology 44(11) 2159-2164 Dalakas MC (2001) Peripheral neuropathy and antiretroviral drugs. J Peripher Nerv Syst 6(l) 14-20 Dalakas MC, Semino-Mora C et al (2001) Mitochondrial alterations with mitochondrial DNA depletion in the nerves of AIDS patients with peripheral neuropathy induced by 2 3 -dideoxycytidine (ddC). Lab Invest 81(11) 1537-1544... 

Martin C, Solders G et al (2000) Antiretroviral therapy may improve sensory function in HIV-infected patients a pilot study. Neurology 54(11) 2120-2127 Masjuan J, Corral I et al (1997) Mycobacterial acute lumbosacral polyradiculopathy as the initial manifestation of AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 15(2) 175 McArthur JC, Yiannoutsos C et al (2000) A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291. Neurology 54(5) 1080-1088... 

Marler JR, Tilley BC, Lu M, Brott TG, Lyden PC, Grotta JC, Broderick JP, Levine SR, Frankel MP, Horowitz SH, Haley Jr. EC, Lewandowski CA, Kwiatkowski TP. Early stroke treatment associated with better outcome the NINDS rt-PA stroke study. Neurology 2000 55 1649-1655. 

Experimental exposure studies have attempted to associate various neurological effects in humans with specific trichloroethylene exposure levels. Voluntary exposures of 1 hours resulted in complaints of drowsiness at 27 ppm and headache at 81 ppm (Nomiyama and Nomiyama 1977). These are very low exposure levels, but the results are questionable because of the use of only three test subjects per dose, lack of statistical analysis, sporadic occurrence of the effects, lack of clear dose-response relationships, and discrepancies between the text and summary table in the report. Therefore, this study is not presented in Table 2-1. No effects on visual perception, two-point discrimination, blood pressure, pulse rate, or respiration rate were observed at any vapor concentration in this study. Other neurobehavioral tests were not performed, and the subjects were not evaluated following exposure. 

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