Neurologic disorders epilepsy

Complexity of inhibition of PLP-dependent enzymes is highlighted by detailed investigations on the inhibition of y-aminobutyric acid aminotransferase (GABA-AT), the enzyme responsible for the degradation of y-aminobutyric acid (GABA), one of the major inhibitory neurotransmitters in the mammalian central nervous system. Inhibition of GAB A-AT results in an increased concentration of GABA in the brain and could have therapeutic applications in neurological disorders (epilepsy, Parkinson disease, and Alzheimer disease). 

Epilepsy is a chronic neurological disorder that affects about 0.6-0.8% of the general population worldwide. The clinical hallmark of epilepsy is... 

Meisler MH, Kearney JA (2005) Sodium channel mutations in epilepsy and other neurological disorders. J Clin Invest 115 2010-2017. 

Cryptogenic epilepsies In these epilepsies the seizures are the result of an underlying neurologic disorder that is often ill-defined or undocumented. Neurologic functions are often abnormal or developmentally delayed in patients with cryptogenic epilepsies. 

Epilepsy A neurologic disorder characterized by recurring motor, sensory, or psychic malfunction with or without loss of consciousness or convulsive seizures. 

Epilepsy A group of neurological disorders characterised by abnormal electrical activity of brain neurons (seizures). 

The epilepsies constitute a common, serious neurological disorder in humans, affecting approximately 60 million people worldwide. Well in excess of 40 distinct epileptic syndromes have been identified to date. Current treatment is only symptomatic except in uncommon instances when surgical treatment is possible. While available antiseizure medications target ion channels such as the y-amino-butyric acid (GABA)a receptor and voltage activated sodium (Na+) channels, current research seeks to elucidate the cellular and molecular mechanisms by which a normal brain becomes epileptic. Hopefully, this research will lead to the identification of new targets for which small molecules can be identified and used for prevention or cure of epilepsy. 

The benzodiazepines are one of the most widely used (and abused) classes of drugs they are widely used in the treatment of epilepsy, insomnia, anxiety, movement disorders, and a variety of other neurological disorders. The discovery of the benzodiazepines is a good example of the importance of serendipity. 

Epilepsy is a chronic neurologic disorder characterized by recurrent seizures.33 Seizures are episodes of sudden, transient disturbances in cerebral excitation that occur when a sufficient number of cerebral neurons begin to fire rapidly and in synchronized bursts.42 Depending on the type of seizure, neuronal activity may remain localized in a specific area of the brain, or it may spread to other areas of the brain. In some seizures, neurons in the motor cortex are activated, leading to skeletal muscle contraction via descending neuronal pathways. These involuntary, paroxysmal skeletal muscle contractions seen during certain seizures are referred to as convulsions. However, convulsions are not associated with all types of epilepsy, and other types of seizures are characterized by a wide variety of sensory or behavioral symptoms. 

Epilepsy A chronic neurologic disorder characterized by recurrent seizures that are manifested as brief periods of altered consciousness, involuntary motor activity, or vivid sensory phenomena. 

Nervous system The existence of neurologic disorders (for example, epilepsy, myasthenia gravis) influences the selection of an anesthetic. So, too, would a patient history suggestive of a genetically-determined sensitivity to halogenated hydrocarbon-induced malignant hyperthermia (see p. 113). 

Cardiovascular disease Coronary artery disease Congestive heart failure Myocardial infarction Neurologic disorders Alzheimer s disease Epilepsy... 

SED-13,1311) (1). Protirelin has neurotransmitter properties and has been used to treat a variety of neurological disorders, including intractable epilepsy (2). Some experiments have also been performed to evaluate its effects in mental disorders. 

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