Neuroleptics cognitive function

Changes in cognitive function during neuroleptic treatment... 

Thus it would appear that neuroleptics have little effect on higher cognitive functioning in schizophrenic patients and that the improvement in attention is facilitated by a non-mesocortical-mesolimbic mechanism. There is also evidence that neuroleptics improve asymmetry in hippocampal function which may be deranged in the illness. It is generally agreed that studies of the effects of neuroleptics on normal subjects, which... 

Anticholinergic drugs are prescribed to people on neuroleptics to reduce extrapyramidal symptoms and they are thought to impair cognitive function. 

Waddington, J., 8c Youssef, H. (1988). Tardive dyskinesia in bipolar affective disorder Aging, cognitive function, course of illness, and exposure to neuroleptics and lithium. American Journal of Psychiatry 145, 613-616. 

Mortimer A (1997) Cognitive function in schizophrenia-do neuroleptics make a difference Pharmacol Biochem Behav 56 789-795. 

Oversedation and/or drowsiness is the most common adverse effect of neuroleptic drugs. However, most patients develop tolerance to this effect. Patients with Alzheimer s disease, as well as having impaired cognitive function and a change in personality, have a tendency to develop sleep-wake cycle disturbances that may be aggravated by classical neuroleptic drugs. 

Although neuroleptic drugs are relatively effective in treating psychiatric symptoms, their mental adverse effects can impair the quality of life of some individuals. The effects of newer neuroleptic drugs on cognitive functioning and the implications for functional outcome have been summarized and methodological and conceptional issues addressed (402). 

Cognitive function is reduced in schizophrenia, and neuroleptic drugs can cause further impairment (411,412). However, the extent to which they do so is... 

Cognitive function is reduced in schizophrenia, and neuroleptic drugs can cause further impairment (362,363). However, the extent to which they do so is disputed. In one study, the more anticholinergic drugs impaired short-term verbal memory (SEDA-18, 48) (364). Another study showed that patients with... 

King, D. and Henry, G., The effect of neuroleptics on cognitive and psychomotor function A preliminary study of helath volunteers. British Journal of Psychiatry 160, 647-653., 1992. 

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