Neuroendocrine cervical carcinoma

Neuroendocrine cervical carcinoma is the second most frequent of the rare histologies. With its heterogeneous appearance and high signal intensity on T2-weighted images,neuroendocrine cervical carcinoma resembles squamous cell carcinoma at MRI. 

This uncommon tumor of bland basaloid cells without mitoses is arranged in palisaded clusters and nests, and it grows in an infiltrative, scattered pattern in the cervical stroma. Squamous metaplasia can occur. The tumor may coexist with other tumors such as squamous cell carcinoma, adenoid cystic carcinoma, or neuroendocrine carcinoma. The basaloid cells express keratin, p63, and pl6 (Fig. 18.12).84-86... 

Extrapolating data from the cervical and pulmonary literature, assorted case reports, and reviews,it appears that small cell and large cell neuroendocrine carcinomas involving endometrium would express chromogranin, synaptophysin, neuron-specific enolase, and CD56 in a significant number of cases. The extent to which these endometrial neuroendocrine carcinomas can express TTF-1 and pi6 has not been studied extensively.It should be noted, however, that... 

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