Rosamine library

Fig. 10 Synthetic scheme for the construction of rosamine library using solid-phase combinatorial approach. Average emission values of fluorescent compounds derived from each rosamine moiety are presented below the structure of rosamine moieties. (All the emission wavelengths were obtained in PBS buffer)...

Ahn YH, Lee JS, Chang YT (2007) Combinatorial rosamine library and application to in vivo glutathione probe. J Am Chem Soc 129 4510-4511... 

Fig. 17.19 Synthesis of rosamine library on solid support, (a) K2C03, Cu, DMF, 130°C (b) H2S04, 80°C (c) modification for R1 (d) SnCl2, EtOH, 90°C (e) 2-chloro-trityl chloride resin, pyr, CH2C12/DMF (f) R2 Grignard reagent, THF, 62°C (g) 1 %TFA, CH2C12...

Y. H. Ahn, J. S. Lee, Y. T. Chang, Selective human serum albumin sensor from the screening of a fluorescent rosamine library. J. Comb. Chem. 2008, 10, 376-380. 

J. Li, H. H. Ha, L. Guo, D. Coomber, Y. T. Chang, Discovery of novel zebraflsh neural tracers by organism-based screening of a rosamine library. Chem. Commun. 2010, 2932-2934. 

Fig. 17.5 Library of coumarin, Dapoxyl, styryl, hemicyanine, and rosamine scaffolds...

Figure 14.12. Rosamine compounds as fluorescent probes, (a) Solid-phase library synthesis (b and c) diverse applications of rosamine sensors derived from image-based live cell and organism screenings. Reproduced with permission from Refs 53, 54, and 56. Copyright 2007-2010 American Chemical Society Reproduced by permission of The Royal Society of Chemistry. Ref 57. (Seethe color version of this figure in Color Plates section.)...

---