Neural inducing factor

Lamb, T.M., Harland, R.M. 1995. Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. Development 121, 3627-3636. 

Green, C.B., Durston, A.J., Morgan, R. 2001. The circadian gene Clock is restricted to the anterior neural plate early in development and is regulated by the neural inducer noggin and the transcription factor Otx2. Mech. Dev. 101, 105-110. 

Inducing factors have already been extracted from cleavage stage embryos of Xenopus laevis (Faulhaber, 1972b). Neuralizing factor, which has been found in Triturus oocytes (Tiedemann, 1953) must be made on maternal messenger. It is not unlikely that other morphogenetic factors are also prelocated in the unfertilized egg. 

Other loci where their interaction with specific receptors (located in target cells) triggers off many biochemical reactions quantitative modification of physiological activity, tissue growth or qualitative alteration of cellular structure and/or function. In that sense, the distinction between hormones and other chemical mediators of cell interaction, such as neural transmitters or embryonic-inducing factors, becomes fuzzy . It rests mainly on the concept of transport. 

Furthermore, PKCe is required for nerve growth factor-induced activation of mitogen-activated protein kinases and neurite outgrowth by ethanol. It is also required for ethanol-induced increases in N-type voltage-gated calcium channels in PC 12 neural cells. 

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