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Neulasta

Molineux G (2004) The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta). Curr Pharm Des 10 1235-1244... [Pg.581]

Pegfilgrastim Neulasta Neutrophil 6 mg SQ one time Bone pain (approximately 25%) Once per cycle dosing Administer 1-3 days after chemotherapy... [Pg.1471]

The N-terminal methionine residue of protein can also be employed for selective PEGylation using aldehyde-terminated PEG via a reductive amination reaction, because the N-terminal primary amine has a lower pAa of 7.8 than other amines such as lysines, whose pZa is 10.1 [7]. After reaction with aldehyde-terminated PEG at low pH, the resultant imine is reduced with sodium cyanoborohydrate to provide PEGylated protein (Fig. 4) [8, 9]. This technique was used for the production of Neulasta, which was approved for use by the FDA in 2002 [10]. [Pg.119]

Neulasta, Pegfilgrastim, G-CSF-PEG Amgen, Inc. Infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelo-suppressive anti-cancer drugs Jan. 2002... [Pg.150]

G-CSF (granulocyte colony-stimulating factor) Nentropenia (low level of nentrophils leading to snsceptibihty to infections) Neulasta, Neupogen... [Pg.96]

Filgrastim [G-CSF] (Neupogen) Oprelvekin (Neumega) Pegfilgrastim (Neulasta)... [Pg.50]

Neulasta (PEGylated filgrastim) Approved Neutropenia Amgen... [Pg.261]

Neulasta (PEGfilgrastim, rPEGyl-ated filgrastim — see Neupogen). Also marketed in EU as Neupopeg... [Pg.502]

Dosage form Neulasta is supplied in 0.6 ml prefilled syringes. Each syringe contains pegfilgrastim 6 mg (based on protein weight) and excipients in a sterile solution. [Pg.158]

Route of administration Neulasta is administered by subcutaneous injection. A physician may determine that a patient or caregiver can safely administer Neulasta at home. [Pg.158]

Recommended dosage and monitoring requirements The recommended dosage of Neulasta is a single subcutaneous injection administered once per chemotherapy cycle. Neulasta should not be administered in the period between 14 days before and 24 hours after administration of cytotoxic chemotherapy. [Pg.158]

Drug interactions No formal drug interaction studies between Neulasta and other drugs have been performed. [Pg.158]

The less-frequent dosing of Neulasta means that patients will require fewer painful injections and fewer office visits. A clinical trial investigator observed, This approval... [Pg.160]

Pegfilgrastim (Neulasta) [Colony Stimulating Factor] Uses i... [Pg.249]

Pegfilgrastim/Neulasta Hematopoietic stimulant Amgen SC Nonlinear PK 15-80 h... [Pg.21]

See other pages where Neulasta is mentioned: [Pg.129]    [Pg.135]    [Pg.7]    [Pg.266]    [Pg.271]    [Pg.7]    [Pg.213]    [Pg.73]    [Pg.177]    [Pg.10]    [Pg.263]    [Pg.944]    [Pg.157]    [Pg.158]    [Pg.160]    [Pg.359]    [Pg.453]    [Pg.478]    [Pg.556]    [Pg.297]    [Pg.301]    [Pg.322]    [Pg.348]    [Pg.759]   
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Granulocyte colony-stimulating factor neulasta)

Neulasta factor)

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