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PEGylated filgrastim

Neulasta (PEGylated filgrastim) Approved Neutropenia Amgen... [Pg.261]

Neulasta (Pegfilgrastim, recombinant PEGylated filgrastim - see Neupogen also marketed in the EU as Neupopeg) Amgen neutropenia 2002 (US and EU)... [Pg.32]

Pharmacokinetics The pharmacokinetics of pegfilgrastim were studied in 379 patients with cancer. The pegylated version of filgrastim demonstrated nonlinear pharmacokinetics, and clearance decreased with increases in dose. Neutrophil receptor binding is an important component of pegfilgrastim clearance, and serum clearance is directly related to the number of neu-... [Pg.158]

Chapter 3) produced by recombinant means in E. coli. It regulates the production of neutrophils and is indicated for the treatment of neutropenia associated with various medical conditions. Neulasta is a PEGylated form filgrastim, also used to treat neutropenia. It exhibits an extended duration of action, due to the PEG-mediated reduction in product renal clearance rate. [Pg.32]

See other pages where PEGylated filgrastim is mentioned: [Pg.266]    [Pg.134]    [Pg.376]    [Pg.189]    [Pg.776]    [Pg.307]    [Pg.266]    [Pg.134]    [Pg.376]    [Pg.189]    [Pg.776]    [Pg.307]    [Pg.1297]    [Pg.271]    [Pg.165]    [Pg.213]    [Pg.263]    [Pg.159]    [Pg.49]    [Pg.27]    [Pg.376]    [Pg.266]    [Pg.1542]    [Pg.1406]    [Pg.1411]    [Pg.550]    [Pg.932]    [Pg.776]    [Pg.808]    [Pg.279]    [Pg.238]    [Pg.15]    [Pg.67]    [Pg.76]    [Pg.563]   
See also in sourсe #XX -- [ Pg.261 , Pg.263 ]



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