Network construction

Chen H, Sharp BM. Content-rich biological network constructed by mining. BMC Bioinformatics 2004 5 147. 

There are commercial computer packages available for handling the network construction, interactions, and calculations involved in what, as will be shown below, is a complicated process. These packages are available for use on both mainframe and microcomputer systems. 

As defined, dendritic networks are considered to result from the one-, two-, and three-dimensional orientation of dendrimers thus ordering can be geometrically likened to rods surfaces or sheets and cubes, tetrahedrons, or spheres, respectively. Due to the broad scope and breadth of potential macromolecular architectures that can be obtained by application of different modes of connectivity, we will herein concentrate on networks constructed from the simplest dendritic structures, namely those that are pseudospheri-cal or globular. The principles that are presented here pertaining to network formation should be easily adaptable to non-spheroidal dendritic structures as well as macromolecular assemblies possessing only limited dendritic character. 

Figure 9.5. An idealized representation of an ordered dendritic network constructed by the procedure of Watanabe and Regen. 81 ...

Ideally, from a macromolecular subunit position control perspective, directed approaches toward network construction are desirable. Indeed, the construction of dendrimers possessing metal-ligating, 4-substituted, 2,2 6, 2"-terpyridine moieties have been reported. 82,83 ... 

Use of this concept for the preparation of networks leads to unlimited architectures. It should facilitate and expand ordered (as well as random) network construction in the future. 

Figure 24 2D honeycomb network constructed from Ni(Hbim)J building blocks (I IB ini = 2,2 -biimidazoleate) linked by N-H N hydrogen bonds in R (l 0) synthons as seen in crystal structure of [K(dibenzo-18-crown-6)][Ni(Hbim)3] 3CH3OH 2H20 [64], Nitrogen and key hydrogen atoms are shaded. 

Figure 10. Schematic representation of the multilayered Pt-DENs/GOx network construction on the electrode using LbL approach (Adapted from Ref. [132]).

The scientific meaning of constructs accrues from the role they play in nomological networks. Construct validation proceeds by establishing functional relationships between assessment vehicles and external criteria with the ultimate aim of tracing the causal directionality of these functions. 

Fig. 1. TEM image of an ultramicrotome of the titania network constructed using a polymer gel template, showing the individual titania nanoparticles of which the structure is composed. Reprinted with permission from [7]. Copyright 2001 American Chemical Society...

Model Networks. Construction of model networks allows development of quantitative structure property relationships and provide the ability to test the accuracy of the theories of mbber elasticity (251—254). By definition, model networks have controlled molecular weight between cross-links, controlled cross-link functionality, and controlled molecular weight distribution of cross-linked chains. Silicones cross-linked by either condensation or addition reactions are ideally suited for these studies because all of the above parameters can be controlled. A typical condensation-cure model network consists of an a, CO-polydimethylsiloxanediol, tetraethoxysilane (or alkyltrimethoxysilane), and a tin-cure catalyst (255). A typical addition-cure model is composed of a, co-vinylpolydimethylsiloxane, tetrakis(dimethylsiloxy)silane, and a platinum-cure catalyst (256—258). 

Crystalline Eu2[Fe( -C5H4C00)2]3(H20)s oo and Gd2[Fe(77 -CsH4COO)2]3(CH30H)2(H20)3 oc, are isostruc-tural and contain a two-dimensional coordination network constructed from the lanthanide-organometallic layers. The two independent ferrocene ligands adopt a synclinal eclipsed and 7 //-periplanar conformation, and each carboxylate group coordinates to a different europium atom generating a two-dimensional brick wall structure. 

Figure 5 The Main Window in Micro Saint for Task Network Construction and Viewing.

The software used, COVISE (Rantzau and Lang 1998), is in principle based on a data flow paradigm found in visualization packages. In contrast to most pure data flow packages, COVISE uses the concept of data and function objects (modules) that can be arbitrarily distributed across machines. The data objects are transferred between hosts using special request broker modules (one for each host). A central controller module is responsible for proper synchronization and execution of a module network constructed beforehand in a visual application builder. 

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