Construction using the network principle

Finally we want to discuss whether structure generation based on the network principle (Subsection 5.3.3) can be used in practice. Consider the amidations of cubane-te-tracarboxylic acid chloride. 

Surprisingly, we obtain 13,035 solutions for 20 amino acids (without specifying multiplicities and using the topological automorphism group). A glance at one of the structures generated reveals what has happened  

In this manner we make sure that these two atoms cannot form a bond unless they are situated in different molecules before the reaction. After applying this modification, the network generator produces the 8855 compounds expected. 

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