Nerve regeneration mechanical properties

Combined with its suitable mechanical properties, impressive nerve regeneration ability, and cytocompatibility, biodegradable PUCL-a/t-PEG nerve repair scaffolds show potential in clinical applications for peripheral nerve repair. 

Biodegradable polyurethanes are of great interest for medical applications because of their variable mechanical properties, biocompatibility, and structural versatility. They are currently used in bone and cartilage applications, as well as in nerve regeneration. 

In contrast, spider silk is devoid of sericin and hence does not evoke the same biological or immunological reactions. Thus, spider silk has better biocompatibility and is a preferred biomaterial for suture applications. It has also been studied as a material for regenerative nerve conduits to promote peripheral nerve regeneration [33]. Silk s unique mechanical properties coupled with its ability to be fabricated into different textile structures enable its use in tissue engineering scaffolds that mimic the mechanical properties of native tissues. For example, silk filaments have been converted into a braided rope stracture that acts as a scaffold for the regeneration of anterior cruciate ligaments (ACL) [34]. 

---