Nerve repair scaffold

In the 1990s, Schakenraad, Robinson, and colleagues performed systematic research on nerve regeneration using scaffolds based on biodegradable copolymers of DL-lactide and s-caprolactone [10,11]. Based on this work, the first and only commercialized artificial nerve repair scaffold was prepared from the biodegradable copolymers of DL-lactide and s-caprolactone [P(DLLA-s-CL)] and is now used clinically under the trade name Neurolac [12],... 

The mechanical properties of a nerve repair scaffold were tested with a universal testing machine (CMT 4204 Sans, Shenzhen, China). Samples were immersed in deionized water for 2h and then tested in a wet state. Tensile strength was studied by applying a force parallel to the axis of a conduit at a speed of 50mm/min. 

The rat glial cell is a crucial cell in the nervous system, which not only connects and supports nerve components but also provides growth factors and distributes nutrients throughout the nervous system [41], Thus these cells were selected to study in vitro cell interactions with nerve repair scaffolds. The cells were seeded onto... 

In vivo degradation of PUCL-aZZ-PEG and PUCL-ran-PEG scaffolds after 9 weeks is shown in Eigure 21.21, which demonstrates significant degradation and tissue compatibility of the PUCL-aZZ-PEG nerve repair scaffolds. According to the in vivo studies, degradation of the scaffolds at the 9th week was accompanied by invasion... 

Combined with its suitable mechanical properties, impressive nerve regeneration ability, and cytocompatibility, biodegradable PUCL-a/t-PEG nerve repair scaffolds show potential in clinical applications for peripheral nerve repair. 

Preparation and characterizations of polyurethane nerve repair scaffolds... 

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