Nerve agents carbamate protection against

Currently, there is no information on performance testing of chemical protective clothing against carbamate nerve agents. Evaluation of fabrics used to prevent exposure to carbamate pesticides may provide guidance on selection of appropriate protective clothing. 

Pyridostigmine is a carbamate that is used in the treatment of myasthenia gravis, a neuromuscular disease. It can also be used as a method of protection against nerve agent poisoning. Carbamates can occupy the catalytic site of acetylcholinesterase (AchE), which temporarily prevents phosphorylation. 

The inadequacy of postexposure therapy for nerve agent casualties, particularly those with potentially lethal exposures to soman, has been of great concern. Development of pyridostigmine, a peripherally active carbamate compound, as a nerve agent pretreatment adjunct has substantially improved the ability of the U.S. military to protect its soldiers from the lethal effects of nerve agents. A major deficiency of this pretreatment program—that it does not protect the CNS against... 

Pre-treatment with the carbamate, p5U idostigmine, is a well-established method to protect against nerve agent intoxication in the armed forces in a number of nations (Aas, 2003). A tablet (30 mg) of p5U idostigmine... 

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