Necrotising enterocolitis

Lucas, A., and Cole, T. J. (1990). Breast milk and neonatal necrotising enterocolitis. Lancet 336, 1519-1523. 

Certain oral medications commonly used in the intensive care of premature infants have very high osmolalities. The high tonicity of enteral feedings has been implicated as a cause of necrotising enterocolitis (NEC). A higher frequency of gastrointestinal illness including... 

Fig. 6.15. Contrast enema showing a stricture of the descending colon following necrotising enterocolitis...

Evennett, N., Cerigioni, E., Hall, N.J., Pierro, A., and Eaton, S. 2014. Smooth muscle actin as a novel serologic marker of severe intestinal damage in rat intestinal ischemia-reperfusion and human necrotising enterocolitis. J Surg Res, 191(2) 323-330. 

Premature infants, and in particular very low birth weight infants, are at risk of developing necrotising enterocolitis (NEC). The mortality of NEC is substantial. Probiotics... 

The efficacy and safety of enteral L-arginine supplementation for the prevention of necrotising enterocolitis in very low birth weight neonates has been evaluated in a randomised, pilot study. No adverse events were observed in the neonates supplemented with L-arginine [97 ]. 

Systematic reviews The relationship between PN and cholestasis and associated liver disease in children has been evaluated. There was inconsistency in evidence regarding prematurity as a risk factor for PNAC. Necrotising enterocolitis was a significant risk factor for PNAC (classes II and III), that the duration and total cumulative dosage of PN are the primary factors associated with the development of PNAC (class II) [113 ]. 

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