Nausea ketoconazole

Itraconazole is usually well tolerated but can be associated with nausea and epigastric distress. Dizziness and headache also have been reported. High doses may cause hypokalemia, hypertension, and edema. Itraconazole, unlike ketoconazole, is not associated with hormonal suppression. Hepatotoxicity occurs in fewer than 5% of cases and is usually manifested by reversible Uver enzyme elevations. 

Nausea, vomiting, and anorexia occur commonly with ketoconazole, especially when high doses are prescribed. Epigastric distress can be reduced by taking ketoconazole with food. Pruritis and/or allergic dermatitis occurs in 10% of patients. Liver enzyme elevations during therapy are not unusual and are usually reversible. Severe ketoconazole-associated hepatitis is rare. 

The cholinesterase inhibitors cause significant adverse effects, including nausea and vomiting, and other peripheral cholinomimetic effects. These drugs should be used with caution in patients receiving other drugs that inhibit cytochrome P450 enzymes (eg, ketoconazole, quinidine see Chapter 4). Preparations available are listed in Chapter 7. 

Nausea or pruritus occurs in approximately 3% of patients taking ketoconazole. More significant adverse effects include gynecomastia, elevations of hepatic enzyme levels, and hepatitis. Caution is advised when using ketoconazole in patients with a history of hepatitis. Routine evaluation of hepatic function is advisable for patients on prolonged therapy. 

Ketoconazole (400 mg/day) has been used for the treatment of hirsutism and acne in women, but adverse effects, such as headache, nausea, loss of scalp hair, hepatitis, and biochemical changes, were impressive (587-589). 

Nevirapine NNRTI 200 mg bid Rash, hepatitis, nausea, headache Dose-escalate from 200 mg qd over 14 days to decrease frequency of rash. Avoid concurrent use with ketoconazole, methadone, and... 

ALCOHOL KETOCONAZOLE May T risk of liver damage. Symptoms of nausea, headache, flushing and discomfort (similar to a disulfiram-type reaction) may occur Additive liver toxicity Be aware... 

Ketoconazole 200-mg tablets - OC 200 mg daily for 7-14 days Most common are nausea, vomiting. 

Imidazoles arc wide-spectnim antifungal drugs to which resistance rarely develops. Except for ketoconazolc. the imidazoles are poorly absorbed orally. Clotrimazole, econii/ule and miconazole are widely used lopic-aliy in the Ireatment of dennaiophyle and Candida alhicam infections. Miconazole is used intravenously in systemic infections in patients who cannot tolerate amphotericin. It may cause nausea and vomiting, faintness and anaphylaxis. Ketoconazole is well absorbed orally, and has been used in Ihe crealment of local and systemic mycoses. Enthusiasm for ketoconazole has declined because it may cause hepatic necrosis and adrenal suppression. 

Ketoconazole. In a double-blind, randomised study, healthy subjects were given slow-release ranolazine 375 mg twice daily for 9 days, with ketoconazole 200 mg twice daily on days 5 to 9. The same study was repeated with ranolazine 1 g twice daily. It was found that ketoconazole increased the AUC, levels (mean, peak and trough) and half-life of ranolazine by 2.5- to 4.5-fold. The most common adverse events were headaches, dizziness and nausea. In some patients the higher dose of ranolazine with ketoconazole resulted in intolerable adverse events. ... 

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