Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Naturally occurring prostaglandins

Chen, S. Janda, K. D. Total Synthesis of Naturally Occurring Prostaglandin F2oc on a Non-Cross-Linked Polystyrene Support, Tetrahedron Lett. 1998, 39, 3943. [Pg.265]

All naturally occurring prostaglandins are derived through the cyclization of 20-carbon unsaturated fatty acids such as arachidonic acid, which in turn is synthesized from the essential fatty acid linoleic acid. The prostaglandins are named according to their ring substitutions and the number of additional side-chain double bands, as seen in prostaglandins E1( Fla, and F2a. [Pg.479]

Several approaches have been used in the clinical application of eicosanoids. First, stable oral or parenteral long-acting analogs of the naturally occurring prostaglandins have been developed. [Pg.446]

Cimino, G., Spinella, A., and Sodano, G., Naturally occurring prostaglandin-1,15-lactones, Tetrahedron Lett., 30, 3589, 1989. [Pg.147]

Despite their range of activities, many naturally occurring prostaglandins would make poor drugs because they are rapidly converted to inactive products. Synthetic modifications can prolong their activity. Misoprostol is a stable synthetic derivative of PGE- that is used for the treatment of ulcers. [Pg.1214]

Dinoprostone is a synthetic preparation of naturally occurring prostaglandin E2. [Pg.194]

Epoprostenol sodium (prostacyclin) is a naturally occurring prostaglandin indicated for the preservation of platelet function during cardiopvdmonary bypass, prevention of platelet aggregation during charcoal hemoperfusion of patients in hepatic failure, euid as an alternative to heparin during rened dialysis. [Pg.318]

Mikolajczyk and Zurawinski [64] elaborated a total, seven-step synthesis of ( )-rosaprostol (162), a trade name for 7-(2-hexyl-5-hydroxycyclopentane)-hep-tanoic acid, showing gastric antisecretory activity and cytoprotective action common to naturally occurring prostaglandins (Scheme 39). The key steps of... [Pg.204]

FIGURE 11.12 Prostaglandins E2 and Fj combinatorial libraries. (From Chen, S. and Janda, K.D., Synthesis of prostaglandin Ej methyl ester on a soluble-polymer support for the construction of prostanoid libraries, J. Am. Chem. Soc., 119, 8724, 1995 Chen, S. and Janda, K.D., Total synthesis of naturally occurring prostaglandin F2on a non-cross-linked polystyrene support. Tetrahedron Lett., 39, 3943, 1998.)... [Pg.258]

Chen, S. and Janda, K.D., Total synthesis of naturally occurring prostaglandin Fj on a non-cross-linked polystyrene support, Tetrahedron Lett., 39, 3943, 1998. [Pg.331]


See other pages where Naturally occurring prostaglandins is mentioned: [Pg.9]    [Pg.2]    [Pg.169]    [Pg.508]    [Pg.23]    [Pg.214]    [Pg.233]    [Pg.389]    [Pg.719]    [Pg.400]    [Pg.409]    [Pg.214]    [Pg.233]    [Pg.400]    [Pg.103]    [Pg.344]    [Pg.347]    [Pg.172]    [Pg.430]    [Pg.22]    [Pg.977]    [Pg.907]    [Pg.2955]    [Pg.400]    [Pg.827]    [Pg.912]    [Pg.912]    [Pg.269]    [Pg.332]    [Pg.1251]    [Pg.142]    [Pg.706]    [Pg.821]    [Pg.357]    [Pg.358]    [Pg.383]    [Pg.392]    [Pg.393]   


SEARCH



Natural Occurence

Naturally-occurring

© 2024 chempedia.info