Natural product libraries Subject

A a,P-unsaturated 5-lactone library, inspired by bioactive natural products such as fostriecin and pironetin (Fig. 4), has been synthesized on a solid support in a highly enantioselective manner using the Lewis acid Ti-(il)-BINOL catalyst 15 (43). After subsequent transformations, a collection of 50 analogues containing structures 17, 18, and 19 were subjected to biological evaluation in phenotype-based screens. A few of them have been shown to be modulators of cell cycle progression and inhibitors of viral entry into cells. 

While the principal value of the book is for the professional chemist or student of chemistry, it should also be of value to many people not especially educated as chemists. Workers in the natural sciences—physicists, mineralogists, biologists, pharmacists, engineers, patent attorneys, and librarians—are often called upon to solve problems dealing with the properties of chemical products or materials of construction. Eor such needs this compilation supplies helpful information and will serve not only as an economical substitute for the costly accumulation of a large library of monographs on specialized subjects, but also as a means of conserving the time required to search for... 

---