Natural killer cell activity assays assessments

Data from KLH-vaccinated cynomolgus monkey infants show an evident TDAR in animals of 3 months of age and a pronunced secondary antibody response to a booster immunization approximately 3 months thereafter (Figure 18.2). Since TDAR requires functional antigen-presenting cells, T cells, and B cells (including the switch to antibody-producing plasma cells), it is supposed to be the most relevant functional assay for a general assessment of immunosuppression. Besides others, another functional assay to be considered for use in juvenile monkeys is a functional test of natural killer (NK) cell activity. 

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