Natriuretic peptide receptors

Nesiritide Agonist of natriuretic peptide receptors Increased sodium and water excretion t vasodilation Heart failure1... 

Endlich K, Steinhausen M Natriuretic peptide receptors mediate different responses in rat renal microvessels. Kidney Int 52 202-207,1997... 

Asu ]-P-ANP(7-28) ([L-a-aminosuberic acid l-P-AMP7.28) is reported to be an ATRIAL NATRIURETIC PEPTIDE receptor ANTAGONIST selective for the type A (ANP ) receptor subtype. 

ATRIAL NATRIURETIC PEPTIDE RECEPTOR AGONISTS include ANP itself (also called atrial natriuretic factor (ANF), or atrlopeptin), a peptide made up of 28 amino acids and is contained in secretory granules in heart atrial cells. ANP is released in response to stretch in the atria, as occurs with increased central venous pressure, thus signalling volume overload in the circulation. The peptide has an effect on the kidney leading to increased Na and water excretion, vasodilation, increased vascular permeability and modified release of a number of other hormones and neurotransmitters. There are at least three related endogenous peptides ANP (atrial natriuretic peptide),... 

ATRIAL NATRIURETIC PEPTIDE RECEPTOR ANTAGONISTS act at receptors recognizing atrial... 

C-type natriuretic peptide (CNP) the newest member of the natriuretic peptide family, was first isolated from porcine brain, and later found in other mammals and nonmammals. It is processed from a pre-pro-CNP molecule, which gives rise to CNP-22 and its N-terminally elongated form. CNP-53. The CNP s share considerable sequence homology with atrial NATRIURETIC PEPTIDES (ANP) and brain natriuretic peptides (BNP). CNP s are atrial NATRIURETIC PEPTIDE RECEPTOR AGONISTS but are more active at the type-B subtype, whereas ANP s are more active at the type-A subtype. 

Natriuretic peptides (ANP, BNP, CNP) were first described by Genest and are now recognized to have several autocrine and paracrine effects within the myocardium and coronary circulation. Natriuretic peptide receptor A (NPR-A) and B (NPR- B) are widely expressed in the cardiovascular system. The natriuretic peptides produce cellular responses through the elevation of intracellular c-GMP concentration that in turn regulates... 

Fig. 6.3 Model ofthe domain structure ofthe natriuretic peptide receptor NPR, a receptor-type guanylyl cyclase. NPR is a dimeric transmembrane receptor which spans the membrane with two transmembrane elements. The extracytosolic domain comprises the ligand binding site and contains several disulfide bridges. The cytosolic part is composed of a kinase homology domain with multiple phosphorylation sites, an ATP binding site of unknown function and the catalytic guanylyl cyclase domain.

Potter, L.R. and Hunter, T. (2001) Guanylyl cyclase-linked natriuretic peptide receptors structure and regulation. J.Biol.Chem., 276, 6057 - 6060. 

Binds to natriuretic peptide receptors, thus T cGMP, resulting in vasodilation ° Used in acutely decompensated CHF... 

C. Clinical Role ANP has been studied for possible use in the treatment of congestive heart failure, but results have been mixed. BNP has showed some benefit in small studies in patients with heart failure. At present there are no clinically important products that act as agonists or antagonists at atrial natriuretic peptide receptors. 

Chinkers M, Garbers DL, Chang MS, et al. A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature 1989 338 78-83. 

Wang, X., Xu, W., Mohapatra, S. et al. 2008b. Prevention of airway inflammation with topical cream containing imiquimod and small interfering RNA for natriuretic peptide receptor. Genet. Vaccines Ther. 6 7. 

Wang Z-Z, Hirose S, Dinger B, Fidone S, Stensaas LJ. Localization of atrial natriuretic peptide receptors in the carotid body. Soc Neurosci Abstr 1991 17 118. 

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