National Library of Medicine TOXNET

The Division of Specialized Information Services (SIS), National Library of Medicine (NLM), creates information resources and services in toxicology, environmental health, chemistry, and HIV/AIDS (SIS 2007). 

SIS s Toxicology and Environmental Health Information Program (TEHIP) produces TOXNET (TOXNET 2007), a collection of toxicology and environmental health databases that includes, among others, the Hazardous Substances Data Bank (HSDB), a database of potentially hazardous chemicals, TOXLINE (containing references to the world s toxicology literature), and ChemIDplus (a chemical dictionary and structure database). 

Some SIS products help to address the toxicology and environmental health information needs of the general public. One such resource is ToxTown, an interactive guide to toxic chemicals and environmental health issues in everyday locations. It is a companion to the extensive information in the TOXNET collection of databases. The Household Products Database is a consumer s guide that provides information on the potential health effects of chemicals contained in more than 5000 common household products used inside and around the home. This database allows consumers, scientists, and health professionals to investigate ingredients in brand-name products. 

Altweb. 2007. The alternatives to animal testing Web site, http //altweb.jhsph.edu/ 

Borenstein, M., Hedges, L., Higgins, J., and Rothstein, H. 2005. Comprehensive Meta-analysis Version 2, Biostat, Englewood NJ. http //www.meta-analysis.com/ 

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HSDB. U.S. Department of Health and Human Services. Hazardous Substances Data Bank. National Library of Medicine, Toxnet File (Bethesda, MD National Institutes of Health, 1989). 

United States National Library of Medicine. Toxnet Toxicology Data Network, http //toxnet.nlm.nih.gov/... 

National Library of Medicine,TOXNET, Hazardous Substances Data Bank, Resorcinol http //toxnet.nlm.nih. gov/cgi-bin/sis/search/r dbs-i-hsdb term+ rn-i-108-46-3 (accessed August 3,2006). 

E. Graedel, D. T. Hawkins, and L. D. Cld,si.toQ., Atmospheric Chemical Compounds, Academic Press, Odando, Fla., 1986, p. 263, cited in Hazardous Substances Data Bank, Acetone from Toxicology Data Network (TOXNET), National Library of Medicine, Bethesda, Md., Jan. 1990, NATS section in the review. 

The solubility is expressed as logarithm of molar fractions log(S). A recommended partition of the data into training and test sets is also taken from the mentioned paper. Six outliers described in Huanxiang et al. (2005) were removed from the considerations. SMILES notations of organic solvents for this study have been obtained with ACD/ChemSketch software (http //www.acdlabs.com/) according to CAS numbers from US National Library of Medicine (http //toxnet.nlm.nih.gov/). 

TOXNET, National Library of Medicine, cluster of databases on toxicology, hazardous chemicals, http //toxnet.nhn.nih.gov. 

TOXNET NATIONAL LIBRARY OF MEDICINE OAK RIDGE NATIONAL LABORATORY... 

National Library of Medicine, Hazardous Substance Data Bank, TOXNET System, Bethesda, MD, 1992. 

National Cancer Institute (NCI)/National Toxicology Program (NTP) National Library of Medicine (NLM)/TOXNET Environmental Protection Agency (EPA)/Gene-Tox NCI/Chemical Carcinogenesis Research Information System (CCRIS) EPA/Integrated Risk Information System (IRIS)... 

IRIS (Integrated Risk Information System). 1998. 1,1,1,2-Tetraflouroethane. CAS No. 811-97-2 in TOXNET(Toxicology Data Network) sponsored by the National Library of Medicine, Toxicology and Environmental Health Information System. [Online]. Available http // toxnet.nlm.nih.gov/cgi-bin/sis/search [9/25/1998, last updated 8/6/1998]. 

This information may be gleaned from specialized ADR resources, texts, and other tertiary sources, including the FDA-approved product label. However, this information must often be augmented using additional data from secondary sources. At minimum, this should include searches of the bibliographic databases from the National Library of Medicine (Medline and Toxnet) and Excerpta Medica (Embase). 

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