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P. J. Baker, ed.. National Institute of Allergy and Infectious Diseases, The Jordan Report, Accelerated Development of Vaccines, 1993, NIH, Bethesda, Md. 

Sampson HA, Munoz-Furlong A, Campbell RL, et 38 al Second symposium on the definition and management of anaphylaxis summary report-Second National Institute of Allergy and Infectious Disease/ 39 Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol 2006 117 391-397. 

This work was supported by Grant GM 27256 from the National Institutes of Health and Grant DA 02507 from the National Institute of Drug Abuse. LL. is an American Cancer Society Research Professor of Biochemistry (Award PRP-21). H.V.V. is the recipient of a Research Career Award (5K6-AI-2372) from the National Institute of Allergy and Infectious Disease. We thank Dr. Y. Hirata of Meijo University for generous gifts of palytoxin isolated from Palythoa tuberculosa. We thank Dr. T. Yasumoto, Tohoku University, Sendai, Japan, for the maitotoxin preparation. We thank also Jeffrey A. Bessette and Nancy Worth for their technical assistance and Inez Zimmerman for preparation of the manuscript. 

Clinical trials performed by the National Institute of Allergy and Infectious Diseases (NIAID) Mycoses Study Group showed that 2 weeks of induction antifungal therapy with combination amphotericin B (0.7 mg/kg per day) plus... 

NIAID National Institute of Allergy and Infectious Diseases... 

Joshua M. Farber Inflammation Biology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA Amy M. Fulton Department of Pathology, School of Medicine, and... 

ACKNOWLEDGMENTS I would like to thank my collaborators who have contributed in this research in many ways, and who are cited in the accompanying references. This investigation was supported by grants from the National Cancer Institute (CA 17625 and CA 54508) and the American Cancer Society (CH 370 and DHP 13E-I), as well as National Institute of Allergy and Infectious Diseases (AI33066). 

ACKNOWLEDGMENTS This work was supported bp a grant from the National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of AIDS, NIH UOl-AI-32485, "Novel Approaches to Therapies for AIDS-Related 01."... 

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ADME-tox absorption, distribution, metabolism, and excretion/toxicologic properties ECS0 median effective concentration IC50 median inhibitory concentration MIC minimum inhibitory concentration MLSMR Molecular Libraries Small Molecule Repository TAACF-NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility/ National Institute of Allergy and Infectious Diseases... 

Inspired by this work (24), we used Bayesian methods (24) with molecular function class fingerprints of maximum diameter 6 (53) to identify substructures that were shown to be important in recent TB screening datasets (21-23). Bayesian models were built with the previously described Molecular Libraries Small Molecule Repository (MLSMR) 220,463 library (4,096 active compounds) (15) and dose-response data using 2,273 molecules (475 active compounds). In addition, these models were tested (15) with the National Institute of Allergy and Infectious Diseases (NIAID) data and GVK Biosciences (Hyderabad, India) datasets used by Prathipati et al. (24). We have validated the models with compounds left out of the original models, in some cases showing up to tenfold enrichments in finding active compounds in the top-ranked 600 molecules (22). 

This investigation was supported in part by grants AI-33066 and AI-077417 (awarded to K. H. Lee) and R44 AI051047 (awarded to G. P. Allaway) from the National Institute of Allergies and Infectious Diseases. 

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