Nasogastric tube feeding

A.L. Clark-Schmidt, et al., Loss of carbamazepine suspension through nasogastric feeding tubes. Am. J. Hosp. Pharmacol. 47 2034-2037, 1990. 

Figure 20-2. Photograph of D.E.C. at 5 months. Note nasogastric feeding tube and...

Clark-Schmidt, A.L. Garnett, W.R. Lowe, D.R. Karnes, H.T. Loss of carbamazepine suspension throu nasogastric feeding tubes. Am.J.Hosp.Pharm., 1990, 47, 2034-2037... 

There are additional requirements for an oral liquid administered via a nasogastric feeding tube ... 

In the request for a pharmacy preparation, the physician often prescribes the administration route. Pharmacists have to critically evaluate whether the proposed route is appropriate to reach the desired bioavailability. For example, conventional oral medications may not be suitable for patients with a nasogastric feeding tube, children, or nauseous patients and alternative routes such as parenteral, rectal, or nasal have to be considered (see also Sect. 37.6.3). When adapting a dosage form or administration route to special needs of a patient, the pharmacist is required to consider safety aspects. It is important to recognise that an active substance approved for oral administration may never have... 

Treatment consists of prevention or elimination of hypoglycaemia. In newborns and infants, this can be achieved by the continuous application of formula diets, if required via nasogastric tube feeding. The administration of allopurinol may also be advisable. A starch diet (e.g. uncooked com starch) is then used to ensure that glucose is released and resorbed slowly in the intestinal tract. (173, 177) After puberty, the course of disease is usually less pronounced. In the long term, espiecially in adenoma-related complications, liver transplantation may be indicated. (185)... 

Nasogastric Tube (NG) This is a tube passed through the nose and into the stomach providing direct access to the stomach. It is used to administer medication, for temporary feeding, and to remove stomach contents. 

Mimoz O, Binter V, Jacolot A, Edouard A, Tod Nf Petitjean O, Samii K. Pharmacokinetics and absolute bioavailability of ciprofloxacin administered through a nasogastric tube with continuous enteral feeding to critically ill patients. Intensive Care Med (1998) 24, 1047-51. 

The absorption of phenytoin can be affected by some foods. A very marked reduction in phenytoin absorption has been described when it was given with enteral feeds (e.g. Isocal, OsmoUte), by nasogastric or jejunostomy tubes. 

A study in 20 patients and 5 healthy subjects found that phenytoin absorption was reduced by about 70% when it was given by nasogastric tube with an enteral feed product (Isocat) at a rate of 100 to 125 mL/hour. Other reports describe the same interaction in patients given Ensure Isocaiydi or Os/nofite. " ... 

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