Nardostachys Valerianaceae

In contrast, valeranes arising from migration of flie methyl group C-15 in eudesmane from C-4 to C-5, in contrast, very rarely occur. Examples include the va-lerenones from the roots of valerian Valeriana officinalis and from Nardostachys jatamansi (Valerianaceae). 

Nardosinanes such as (-)-kanshone A, including some struetural variants, and nar-dosinone, a 1,2-dioxolane (cyclie peroxide) isolated from Nardostachys chinensis (Valerianaceae) formally emerge from eremophilane by migration of the isopropyl-group from C-7 to C-6. 

Lee et al. also reported a total synthesis of iridolactone, 7-hydroxy-8-(hydroxymethyl)-4-methylenehexahydrocyclopenta[c]-pyran-l-(3 H)-one (79) via intramolecular Pd(0)-catalyzed allylic alkylation [110]. This iridolactone was isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae) [111]. The plant exhibited a variety of biological activities such as sedative, antimalarials, antinociceptive, cytotoxic, and enhancement of nerve growth factor activities [112]. 

The term nardosinane comes from the terrestrial plant Nardostachys chinensis (Valerianaceae). ll,12-Epoxynardosin-l(10)-ene is the first example of nardosinane isolated from a gorgonian (Kelecom et al, 1990). 

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