Nardostachys chinensis

The new diterpene, 10-isopropyl-2,2,6-trimethyl-2,3,4,5-tetrahydronaphtho[l,8-/fc]oxocine-5,ll-diol 48 was obtained as colorless crystals from the roots of Nardostachys chinensis <2005JNP1131>. The structure of 48, a naphthalene nucleus fused with an oxocine ring, was established by spectroscopic data, mainly NMR, and confirmed by X-ray crystallographic analysis. 

Nardosinanes such as (-)-kanshone A, including some struetural variants, and nar-dosinone, a 1,2-dioxolane (cyclie peroxide) isolated from Nardostachys chinensis (Valerianaceae) formally emerge from eremophilane by migration of the isopropyl-group from C-7 to C-6. 

Haneyama, H. and Kagatani, M. 2007. Sedatives containing Nardostachys chinensis extracts. CAN 147 197215. 

Biotransformation of (+)-1(10)-Aristolene (36) from THE Crude Drug Nardostachys chinensis by Chlorella fusca, Mucor Species, and Aspergillus niger... 

The structure of sesquiterpenoid (+)-l(10)-aristolene (=calarene) (36) from the crude drug Nardostachys chinensis was similar to that of nootkatone. 2-Oxo-l(10)-aristolene (38) shows antimelanin-inducing activity and excellent citrus fragrance. On the other hand, the enantiomer (37)... 

Nardostachys chinensis by Chloreua fusca, Mucor species, and Aspergillus nicer... 

Lee et al. also reported a total synthesis of iridolactone, 7-hydroxy-8-(hydroxymethyl)-4-methylenehexahydrocyclopenta[c]-pyran-l-(3 H)-one (79) via intramolecular Pd(0)-catalyzed allylic alkylation [110]. This iridolactone was isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae) [111]. The plant exhibited a variety of biological activities such as sedative, antimalarials, antinociceptive, cytotoxic, and enhancement of nerve growth factor activities [112]. 

Zhang Y, Lu Y, Zhang L, Zheng QT, Xu LZ, Yang SL (2005) Terpenoids from the roots and rhizomes of Nardostachys chinensis. J Nat Prod 68 1131-1133... 

Tanitsu MA, Takaya Y, Akasaka M, Niwa M, Oshima Y (2002) Guaiane- and aristolane-type sesquiterpenoids of Nardostachys chinensis roots. Phytochemistry 59 845-849... 

The term nardosinane comes from the terrestrial plant Nardostachys chinensis (Valerianaceae). ll,12-Epoxynardosin-l(10)-ene is the first example of nardosinane isolated from a gorgonian (Kelecom et al, 1990). 

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