2- Naphthyl chloroformate

Fluorenylmethyl chloroformate and its analogs (2-naphthyl chloroformate (NT-COCl), 9-fluorenyl-methyl chloroformate (FMOC-Cl), and 2-(l-pyre-nyl)ethyl chloroformate (PE-COCl)) are used as precolrunn derivatization reagents for HPLC. 

Rates of solvolysis of cinnamoyl chloride and its 4-chloro and 4-nitro derivatives were analysed using the simple and extended Grunwald-Winstein equations. Studies of solvent effects in the solvolysis of isopropenyl, isobutyl,and propargyl chloroformate " and of 1- and 2-naphthyl chloroformate were reported. 

Naphtho-thietes, 21 151 Naphtol products, 9 281 1-Naphthylacetic acid derivatives, 12 176 1-Naphthyl chloroformate, molecular formula, 6 291t... 

During the preparation of aryl chloroformates, it is essential to keep the reaction mixture really cold during water washing to prevent vigorous decomposition. Phenyl and naphthyl chloroformates may be distilled, but benzyl chloroformate is too thermally unstable. 

SYNS CARBANOCHLORIDIC ACID, NAPHTHYL ESTER CARBONOCHLORIDICACID, 1-NAPHTH-ALENYL ESTER CHLOROFORMIC ACID, ESTER with 1-NAPHTHOL CHLOROFORMIC ACID 1-NAPHTHYL ESTER CHLOROMROWCZAN 1-NAFTYLU (CZECH) 1-NAPHTHYL CHLOROCARBONATE a-NAPHTHYL CHLOROFORMATE... 

NAPHTHYL CHLOROFORMATE see NBH200 a-NAPHTHYL CHLOROFORMATE see NBH200 P-NAPHTHYDDI-(2-CHLOROETHYL)AMINEsee BIF250... 

Phenyl and naphthyl chloroformates may be distilled, but benzyl chloroformate is... 

Lambrech of Union Carbide Corporation was issued two patents (19-20) covering the synthesis of 1-naphthyl N-methylcarbamate, known by the tradename Sevin, and its use as a insecticide. In method 1, 1-naph-thol or its sodium salt reacted with phosgene to give 1-naphthyl chloroformate which when reacted with methylamine afforded Sevin in excellent yield. 

Gore et al.426 have used chloroform as a solvent for acetylation catalysed by aluminium chloride and at 45-55 °C find that a 2-methoxy substituent in naphthalene increases the reactivity of the 1 position 1.72 times, of the 6 position 3.8 times, and of the 8 position, 0.9 times the former and latter of these results indicate a considerable steric effect. Likewise, a 2-bromo substituent caused the reactivity of the 6 and 8 positions to be 0.63 and 0.58 times that of the corresponding positions in the unsubstituted compound. At 20-25 °C the relative reactivities of some polycyclics were as follows427 1-naphthyl, 1.0 3-phenanthryl 0.64 9-phenanthryl, 0.02 1-phenanthryl, 0.29 2-naphthyl, 0.28 2-phenanthryl, 0.12 4-phenanthryl, 0.0085. Some of these results seem to be due to steric hindrance, and the large difference in reactivity of naphthalene and biphenyl seems erroneous. 

Lippi et. al (87) and Dirstine (88) circumvented titration by converting the liberated fatty acids into copper salts, which after extraction in chloroform are reacted with diethyldithio-carbamate to form a colored complex which is measured photometrically. While the end point appears to be more sensitive than the pH end point determination, the advantages are outweighed by the additional steps of solvent extraction, centrifugation and incomplete extraction when low concentrations of copper salts are present. Other substrates used for the measurement of lipase activity have been tributyrin ( ), phenyl laurate (90), p-nit ro-pheny1-stearate and 3-naphthyl laurate (91). It has been shown that these substrates are hydrolyzed by esterases and thus lack specificity for lipase. Studies on patients with pancreatitis indicate olive oil emulsion is definitely superior to water soluble esters as substrates for measuring serum lipase activity. 

Compound 1 is completely hydrogenated to the saturated ketone, 4-(6-methoxy-2-naphthyl)-3-butan-2-one. Compound 2 is hydrogenated in high ytield (90%) to the saturated ketone, 2-acetyl-5,8-dimethoxy-tetrahydro-naphthalene, which can be obtained in the pure form by fractional crystallization from chloroform. 

Barriers to Rotation and Equilibrium Constants of 9-(2-Hydroxy-l-naphthyl)fluorene Benzoates (65) in Chloroform-d at 69°C... 

Optica] resolution of these and related carboxylic acids were achieved using salt formation with alkaloids (strychnine, brucine, cinchonidine) 33,39,44 or with optically active amines [1-phenyl- or l-( 3-naphthyl)ethylamine]4o,44). The following rotations [a]D have been reported [8]paracyclophanecarboxylic acid (13) +18° (chloroform)441 [10]homologue (14) +80° (chloroform)39 and +67° (chloroform)40 its methyl-derivative (75) —28° (methanol)44 . Dioxa[10]paracyclophanecarboxylic acid (16) + 104° (ethanol)36 and bromo-dioxa[12]paracyclophanecarboxylic acid (79) —37° (acetone)33). 

The complexes of the monothio-/3-diketonate RC(SH)=CHCOR (R = R = phenyl R = phenyl, 2-thienyl, j8-naphthyl R = CF3), which are acetylacetonate analogues have been synthesized (242).1143 Dipole moment measurements are consistent with facial structures (243). Mass spectra indicate no metal-containing peaks for the complex [Cr(PhC(S)=CHCOPh)3)] however, for the fluorinated monothio-j8-diketonates, various metal-containing peaks, e.g. M—2b=F, were observed. Such ions involve fluoride migration. Monothiooxalate complexes of chromium(III) have been prepared fairly unusual complexes, exemplified by [Cr (C2S03)Cu(Ph3)2 3], were reported. On refluxing under chloroform (7h) reactions of the kind illustrated were alleged to occur (equation 55). 44... 

Di-a-naphthyl selenium dichloride,1 (C10H7)2SeCl2.—The corresponding selenide is dissolved in ether and dry chlorine passed in, when an amorphous white precipitate separates. Recrystallisation from xylene yields colourless prisms, 3VI.pt. 130° C., insoluble in alcohols, ether, chloroform, benzene, ligroin and carbon disulphide. 

Seleno-jS-naphthyl methyl ether forms needles, M.pt. 162° C., easily soluble in chloroform, less soluble in alcohol. The corresponding ethyl ether separates as pure white needles, M.pt. 176° C. 

Di-a-naphthyl methyl tellurium iodide,2 (C1oH7)2(CH3)TeI, crystallises in small needles, melting with decomposition at 146° C., insoluble in chloroform. 

Di-a-naphthyl tellurium di-iodide, (C10H7)2TeI2,2 is obtained in quantitative yield by the usual method. It forms Bordeaux-red needles, M.pt. 184° to 186° C., soluble in benzene, toluene, xylene, chloroform or carbon disulphide, sparingly soluble in petroleum ether or alcohols. 

Bromination of 2-methyl-,447, 481 7-methyl-,78,478 5-bromo-,76 2-fluoro-,482 or 2-phenylbenzo[6]thiophene483 in either chloroform or carbon tetrachloride gives the 3-bromo compound in each case. 2-(2-Naphthyl )benzo[6]thiophene is brominated,54 chlorinated, and iodinated484 in the 3-position. In the cases of 3-methyl-485 and 3-bromobenzo[6]thiophene,107 bromination takes place in the 2-position. Bromination of 2,3-dimethylbenzo[6]thiophene in dilute chloroform solution at 0° gives mainly nuclear substitution in the 6-position,81 but chlorination in acetic acid causes substitution in the 2-methyl group, to give 2-chloromethyl-3-methvlbenzo[6]thiophene.419... 

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