Nanostructured gold surface

D. (2007) Highly sensitive detection of dye-labelled DNA using nanostructured gold surfaces. Chemical Communications, 2811-2813. 

P. Tessier, S. Christesen, K. Ong, E. Clemente, A. Lenhoff, E. Kaler and O. Velev, On-line spectroscopic characterization of sodium cyanide with nanostructured gold surface-enhanced Raman spectroscopy substrates, Appl. Spectrosc. 56, 1524 (2002). 

Our results concerning the increase of SERS with distance from siuface of nanostructured gold surface are in good agreement with predictions by... 

Sackmann, M., Bom, S., Balster, T. and Materny, A. (2007) Nanostructured gold surfaces as reproducible substrates for surface-enhanced Raman spectroscopy. Journal of Raman Spectroscopy, 38, 277-82. 

Fig. 24 Nanografting of ssDNA on gold surface. Top row different squares of oligonucleotide nanostructure grafted within a SAM layer. Bottom row corresponding cursor profile as indicated above [129]. Reprinted with permission...

Even though it has been claimed that this approach will open an interesting route towards the formation of nanostructures on surfaces it has been exploited to a much lesser extent then, for example, the reconstructed Au(l 11)-(V3 X 22) surface and the vicinal gold surfaces. Recently a new system has been proven to act as a growth template, which consists of a graphene... 

However, hybrid bilayers are not suitable for protein incorporation because water is needed at the inner part of the bilayer to avoid protein denaturalization. In order to avoid this problem, Au surfaces were functionalized with a short hydroxylated dithiol (dithiothreitol, DTT) which adopts a lying down configuration with the OH groups exposed to the environment. Vesicle fusion on these DTT surfaces allows phospholipid bilayer formation with a water layer between the DTT SAM and the inner phospholipid monolayer. The phospholipid bilayer exhibits good fluidity as has been shown by in situ AFM (atomic force microscopy) imaging. These bilayers have been formed on both planar and nanostructured [SERS (surface enhanced Raman spectroscopy) active] gold surfaces. ... 

At the same time that reduction of the nitro group occurs in NBT SAMs, cross-linking also occurs between adjacent biphenyl groups. This may be exploited to yield micro- and nanostructures. Eck et al. showed that freestanding sheets of cross-linked biphenyls may be formed by electron-induced cross-hnking and released by exposure of the samples to iodine vapor (which oxidizes the S-Au bond). Alternately, NBT SAMs may be cross-linked and the unexposed adsorbates removed by thermal desorption (thiols readily desorb from gold surfaces because the activation barrier for conversion of two thiolates to a disulfide is small). ... 

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