Nanogels structural types

FIGURE 16.1 Principal structural types of micro- and nanogels (a) Cross-linked networks, (b) networks associated with hydrophobic domains (e.g., cholesterol molecules), (c) core-shell structure of two different networks, (d) multilayer networks (microgel covered with two polyelectrolyte layers is shown), (e) composite solid core-soft shell networks containing metal, ceramic, or protein NPs, (f) composite raisin-in-pie type of microgel with metal NPs dispersed in the network. 

Liu et al. reported the preparation of two types of shell-cross-linked (SCL) micelles with inverted structures via click chemistry starting from a well-defined schizophrenic water-soluble triblock copolymer in purely aqueous solution. They present an efficient synthesis of two types of SCL micelles with either pH- or temperature-sensitive cores from a novel poly(2-(2-methoxyethoxy) ethyl methacrylate)-ft-poly(2-(dimethylamino) ethyl methacrylate)-Z -poly(2-(diethylamino) ethyl methacrylate) [PME02MA-ft-P(DMA-co-QDMA)- -PDEA] triblock copolymer. First, PMEO2MA- -PDMA- -PDEA was prepared and the DMA blocks were partially converted to a quaternized DMA (QDMA) block with click-cross-linkable moieties to form novel schizophrenic water-soluble triblock copolymers. The pH- or temperature-induced micellization and subsequent shell cross-linking of the P(DMA-co-QDMA) inner shell with the tetra-(ethylene glycol) diazide via click chemistry resulted in nanogel networks (Figure 54.14). 

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