Named reactions Barbier reaction

BAMBERGER Benzotnazine synthesis 17 BAMFORD - STEVENS CAGLIOTI - SHAPIRO Reaction 18 BARBIER Reaction 19 BARBIER - VnlELAND DegradaUon 20 BART SCHEUER Arsonylation 21 BARTON Name photolysis 22 BARTON Deamination 23 BARTON Decarboxylation 24... 

One of the great and important steps in the history of modern chemistry was made by Philippe Barbier [1] when, in 1899, he started his work in the area of organomagnesium chemistry. In doing so he discovered the one-step reaction that was to be named after him the Barbier Reaction. 

The most systematic name would be the one in which the procedure is made clear to the reader such as one-pot reaction (e.g. in [30] and [31]) or one-flask reaction, in situ reaction [32], one-step reaction [33], etc. and such names are often encountered. However more often names such as modified) Wagner-Saytzejf reaction, Saytzeff reaction, Barbier-Grignard reaction [29], [34], [35] and [36], batch-method [36], Dreyfuss-Barbier reaction [37], Jaworsky reaction [38], Grignard-type reaction [39], [40], etc. are used. 

More recently [41-43] the name Barbier reaction has also been linked up to one-step processes in which metals, different from magnesium, are applied (see chap 3). In this monograph preference is given to names for such processes in which the applied metal is recognizable hence names such as Li-Barbier or Zn-Barbier etc. reactions will be used. 

Magnesium was among the metals used for, what the authors - in a following publication - had named an electroassisted Barbier reaction [102] (see also Sect. 3.5, p. 129). 

As for the names of these reactions with metals, other than magnesium, it has already been stated in Chapter One that preference will be given to the name Barbier-type reaction instead of simply Barbier reaction. Furthermore the name of each individual metal will be included in the indication of the processes hence there will be mention of Li-Barbier reactions, Zn-Barbier reactions and so on. 

As an example, let us look at a method for acetylating aromatic amines in aqueous solution. This reaction has a special name—the Lumiere-Barbier method. We shall consider the acetylation of aniline PhNH2 (a basic aromatic amine) using acetic anhydride. The procedure for this reaction is as follows. 

The Barbier [100,101], Bouveauit [102] and Reformatsky reactions [103], to name a few of the many that can be acceierated by US, have not yet been addressed in anaiyticai sono-chemistry. Modeis of controiied and caicuiabie time averaged rate of mass transfer to and from the interface [104] can be highiy usefui in this context. 

Barbier 1899. A few years later Barbier investigated using magnesium in place of zinc in what he named la methode generate imaginee par Saytzeff, the Saytzeff reaction, for the preparation of a tertiary alcohol, using diethyl ether as the solvent [1] ... 

Name of the One-step Procedure. Early publications in this new field of organic chemistry reveal a bitter rivalry over priority and eponimy between the stu-dent/assistant Grignard (Nobel-prize winner 1912) and the teacher/head-of-the-department Barbier. Several modern historians have come to the conclusion [29] that the most reasonable name for this step-wise procedure would have been Barbier-Grignard reaction. 

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